Method and apparatus for performing optical imaging using frequency-domain interferometry

Patent metadata

Field	Value
Publication number	US-9377290-B2
Application number	US-201414256361-A
Country	US
Kind code	B2
Filing date	Apr 18, 2014
Priority date	Oct 27, 2003
Publication date	Jun 28, 2016
Grant date	Jun 28, 2016

Abstract

An apparatus and method are provided. In particular, a radiation can be provided which includes at least one first electro-magnetic radiation directed to a sample and at least one second electro-magnetic radiation directed to a reference, whereas a frequency of the radiation varies over time. An interference between at least one third radiation associated with the first radiation(s) and at least one fourth radiation associated with the second radiation(s) can be detected to generate an electrical first signal. A second signal associated with at least one phase of at least one frequency component of the electrical first signal can be obtained. Further, comparison data can be generated by comparing the second signal to at least one particular information.

First claim

The invention claimed is:

1. An apparatus, comprising:
at least one first arrangement including a light source that is configured to provide a radiation which includes at least one first electro-magnetic radiation directed to a sample and at least one second electro-magnetic radiation directed to a reference, wherein the light source causes a frequency of the radiation provided by the at least one first arrangement to vary over time;
at least one second arrangement including a detector that is configured to detect an interference between at least one third radiation associated with the at least one first radiation and at least one fourth radiation associated with the at least one second radiation to generate an electrical first signal, wherein the at least one second arrangement is configured to obtain a second signal associated with at least one phase of at least one frequency component of the electrical first signal; and
a computer which generates comparison data by comparing the second signal to at least one particular information.

2. The apparatus according to claim 1 , wherein the at least one second arrangement is configured to determine a third signal associated with at least one further phase of at least one further frequency component of the electrical first signal, and wherein the at least one particular information is the third signal.

3. The apparatus according to claim 1 ,
wherein the at least one second arrangement is configured to determine a third signal associated with at least one further phase of at least one further frequency component of a further electrical signal, the further electrical signal being different from the electrical first signal, and
wherein the at least one particular information is the third signal.

4. The apparatus according to claim 3 , wherein the electrical first signal and the further electrical signal are obtained at different times.

5. The apparatus according to claim 3 , wherein the electrical first signal and the further electrical signal are obtained at different locations of the sample.

6. The apparatus according to claim 1 , further comprising
at least one structural third arrangement including an interferometer that is configured to generate a third signal associated with the radiation, wherein the at least one second arrangement is configured to provide the at least one particular information based on the third signal.

7. The apparatus according to claim 1 , further comprising at least one structural third arrangement including an interferometer that is configured to receive at least one portion of the radiation, and provide a further radiation so as to generate a third signal, wherein at least one of the second signal or the at least one particular information is associated with the further radiation.

8. The apparatus according to claim 1 , wherein the at least one second arrangement is configured to detect a third signal corresponding to the electrical first signal between the at least one third and fourth radiations, and wherein the second signal is associated with at least one phase of at least one frequency component of an additional electrical signal associated with the third signal.

9. A method comprising:
providing a radiation which includes at least one first electro-magnetic radiation directed to a sample and at least one second electro-magnetic radiation directed to a reference, wherein a frequency of the radiation varies over time;
detecting an interference between at least one third radiation associated with the at least one first radiation and at least one fourth radiation associated with the at least one second radiation to generate an electrical first signal;
obtaining a second signal associated with at least one phase of at least one frequency component of the electrical first signal; and
generating comparison data by comparing the second signal to at least one particular information.

10. The method according to claim 9 , further comprising determining a third signal associated with at least one further phase of at least one further frequency component of the electrical first signal, and wherein the at least one particular information is the third signal.

11. The method according to claim 9 , further comprising:
determining a third signal associated with at least one further phase of at least one further frequency component of a further electrical signal, the further electrical signal being different from the electrical first signal,
wherein the at least one particular information is the third signal.

12. The method according to claim 11 , wherein the electrical first signal and the further electrical signal are obtained at different times.

13. The method according to claim 11 , wherein the electrical first signal and the further electrical signal are obtained at different locations of the sample.

14. The method according to claim 9 , further comprising detecting a third signal corresponding to the electrical first signal between the third and fourth radiations, wherein the third signal is associated with at least one phase of at least one frequency component of an additional electrical signal associated with the third signal.

15. A system comprising:
at least one arrangement including (i) a detector that is configured to detect an interference between at least one first radiation associated with a first split portion of a radiation received from a sample and a second split portion of the radiation received from a reference and (ii) a computer configured to cause a generation of an electrical first signal associated with the interference, wherein a frequency of the radiation varies over time, and wherein the at least one arrangement including an interferometer that is configured to obtain a second signal associated with at least one phase of at least one frequency component of the electrical first signal, and wherein the computer generates comparison data by comparing the second signal to at least one particular information.

16. The apparatus according to claim 15 , wherein the detector is configured to detect a third signal corresponding to the electrical first signal between the first and second split portions of the radiation, and wherein the second signal is associated with at least one phase of at least one frequency component of an additional electrical signal associated with the third signal.

Assignees

• Gen Hospital Corp

Inventors

• Yun Seok-Hyun
• Bouma Brett Eugene
• Tearney Guillermo J
• De Boer Johannes Fitzgerald

Classifications

• G01B9/02002

  using two or more frequencies · CPC title

• H01S3/0071

  Beam steering, e.g. whereby a mirror outside the cavity is present to change the beam direction · CPC title

• A61B5/7257

  using Fourier transforms · CPC title

• G01B2290/70

  Using polarization in the interferometer · CPC title

• G01B2290/45

  Multiple detectors for detecting interferometer signals · CPC title