Methods and compositions related to inhibition of viral entry
US-2016354428-A1 · Dec 8, 2016 · US
Cyclin based inhibitors of CDK2 and CDK4
US9376465B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9376465-B2 |
| Application number | US-201414492753-A |
| Country | US |
| Kind code | B2 |
| Filing date | Sep 22, 2014 |
| Priority date | Mar 27, 2012 |
| Publication date | Jun 28, 2016 |
| Grant date | Jun 28, 2016 |
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- Title
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Abstract
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Structural and functional analysis of peptide inhibitor binding to the cyclin D and cyclin A groove has been investigated and used to design peptides that provide the basis for structure-activity relationships, have improved binding and have potential for development as chemical biology probes, as potential diagnostics and as therapeutics in the treatment of proliferative diseases including cancer and inflammation.
First claim
Opening claim text (preview).
What is claimed is: 1. A synthetic CDK/cyclin inhibitor that inhibits interaction of a complex formed between a first CDK protein and a first cyclin protein with a substrate of the complex, the synthetic CDK/cyclin inhibitor having the following structure: wherein R1 is methyl and R2 has the following structure:
Assignees
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Classifications
with the first amino acid being basic · CPC title
and aromatic or cycloaliphatic · CPC title
with the first amino acid being heterocyclic · CPC title
Tripeptides · CPC title
- C07K5/1024Primary
with the first amino acid being heterocyclic · CPC title
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- What does patent US9376465B2 cover?
- Structural and functional analysis of peptide inhibitor binding to the cyclin D and cyclin A groove has been investigated and used to design peptides that provide the basis for structure-activity relationships, have improved binding and have potential for development as chemical biology probes, as potential diagnostics and as therapeutics in the treatment of proliferative diseases including can…
- Who is the assignee on this patent?
- Univ South Carolina
- What technology area does this patent fall under?
- Primary CPC classification C07K5/1024. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Jun 28 2016 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).