Tricyclic condensed heterocyclic compound, process of producing same, and use thereof

Patent metadata

Field	Value
Publication number	US-9376415-B2
Application number	US-201013259227-A
Country	US
Kind code	B2
Filing date	Mar 24, 2010
Priority date	Mar 30, 2009
Publication date	Jun 28, 2016
Grant date	Jun 28, 2016

Abstract

A compound derived from the culture product of an actinomycete and having an antitumor activity is provided. Provided is a compound represented by any one of formulas (I), (II) and (III)
or an optical isomer thereof or a pharmaceutically acceptable salt thereof

which can be isolated from the culture fluid of an actinomycete which belongs to the genus Streptomyces , wherein R 1 , R 2 , R 5 and R 6 each independently represent a hydrogen atom, a methyl group, a hydroxymethyl group, a hydroxyl group, or a double bond by which R 1 and R 2 or R 5 and R 6 are bonded; R 3 , R 4 , R 7 and R 8 each independently represent a methyl group or a hydroxymethyl group; and R 9 represents a hydrogen atom or a hydroxyl group.

First claim

The invention claimed is:

1. A process for producing a compound of formula (I), (II) or (III)

or an optical isomer thereof or a pharmaceutically acceptable salt thereof, wherein R 1 , R 2 , R 5 and R 6 each independently represent a hydrogen atom, a methyl group, a hydroxymethyl group, a hydroxyl group, or represent a double bond by which R 1 and R 2 or R 5 and R 6 are bonded; R 3 , R 4 , R 7 and R 8 each independently represent a methyl group or a hydroxymethyl group; and R 9 represents a hydrogen atom or a hydroxyl, the process comprising culturing a microorganism capable of producing the compound of formula (I), (II) or (III); and isolating the compound of formula (I), (II) or (III) from a product of the culturing, wherein the microorganism is cultured in a culture medium comprising about 2.5 weight percent glucose.

2. The process of claim 1 , wherein the microorganism capable of producing the compound of formula (I), (II) or (III) is a microorganism which belongs to the genus Streptomyces.

3. The process of claim 1 , wherein the microorganism capable of producing the compound of formula (I), (II) or (III) is Streptomyces sp. NPS643 or a variant thereof.

Assignees

• Sato Seizo
• Iwata Fumie
• Yamada Shoichi
• Takeo Jiro
• Abe Akihisa
• Kawahara Hiroyuki
• Nippon Suisan Kaisha Ltd

Inventors

• Sato Seizo
• Iwata Fumie
• Yamada Shoichi
• Takeo Jiro
• Abe Akihisa
• Kawahara Hiroyuki

Classifications

• A61P35/00

  Antineoplastic agents · CPC title

• C12P17/04

  containing a five-membered hetero ring, e.g. griseofulvin {, vitamin C} · CPC title

• C07D307/93 Primary

  condensed with a ring other than six-membered · CPC title

• C07D307/77 Primary

  ortho- or peri-condensed with carbocyclic rings or ring systems · CPC title

• C12R1/465

  Chemistry & Metallurgy · mapped topic