Hemostatic sponge

Patent metadata

Field	Value
Publication number	US-9375505-B2
Application number	US-201414184543-A
Country	US
Kind code	B2
Filing date	Feb 19, 2014
Priority date	Apr 7, 2010
Publication date	Jun 28, 2016
Grant date	Jun 28, 2016

Abstract

The present invention provides a hemostatic porous composite sponge comprising
i) a matrix of a biomaterial and ii) one hydrophilic polymeric component comprising reactive groups wherein i) and ii) are associated with each other so that the reactivity of the polymeric component is retained, wherein associated means that
said polymeric component is coated onto a surface of said matrix of a biomaterial, or said matrix is impregnated with said polymeric material, or both.

First claim

What is claimed is:

1. A hemostatic porous composite sponge, comprising:
a matrix of a biomaterial; and
a single hydrophilic polymeric component comprising one or more reactive groups,
wherein the matrix and the single hydrophilic polymeric component are associated with each other so that:
the reactivity of the single hydrophilic polymeric component is retained.

2. The hemostatic porous composite sponge claim 1 , wherein the biomaterial is selected from the group consisting of collagen, gelatin, fibrin, a polysaccharide, a synthetic biodegradable biomaterial, and derivatives thereof.

3. The hemostatic porous composite sponge of claim 2 , wherein the polysaccharide comprises chitosan.

4. The hemostatic porous composite sponge of claim 2 , wherein the synthetic biodegradable biomaterial comprises polylactic acid or polyglycolic acid.

5. The hemostatic porous composite sponge of claim 1 , wherein the single hydrophilic polymeric component comprises a polyalkylene oxide polymer.

6. The hemostatic porous composite sponge of claim 5 , wherein the polyalkylene oxide polymer comprises polyethylene glycol (PEG).

7. The hemostatic porous composite sponge of claim 5 , wherein the polyalkylene oxide polymer comprises a multi-electrophilic polyalkylene oxide polymer.

8. The hemostatic porous composite sponge of claim 5 , wherein the polyalkylene oxide polymer comprises a multi-electrophilic polyethylene glycol (PEG).

9. The hemostatic porous composite sponge of claim 5 , wherein the polyalkylene oxide polymer comprises pentaerythritolpoly(ethyleneglycol)ether tetrasuccinimidyl glutarate.

10. The hemostatic porous composite sponge of claim 1 , wherein the biomaterial is collagen, wherein the polymeric component is pentaerythritolpoly(ethyleneglycol)ether tetrasuccinimidyl glutarate, and wherein the single hydrophilic polymeric component is coated onto the collagen.

11. The hemostatic porous composite sponge of claim 1 , wherein the biomaterial is collagen, wherein the polymeric component is pentaerythritolpoly(ethyleneglycol)ether tetrasuccinimidyl glutarate, and wherein the single hydrophilic polymeric component is impregnated into the collagen.

12. The hemostatic porous composite sponge claim 1 , wherein the single hydrophilic polymeric crosslinker is coated onto a surface of the matrix.

13. The hemostatic porous composite sponge claim 1 , wherein the matrix is impregnated with the single hydrophilic polymeric crosslinker.

14. The hemostatic porous composite sponge claim 1 , wherein the matrix is impregnated with the single hydrophilic polymeric crosslinker, and wherein the single hydrophilic polymeric crosslinker is coated onto a surface of the matrix.

15. A method of treating an injury, comprising:
administering a hemostatic porous composite sponge to the injury, the sponge comprising:
a matrix of a biomaterial; and
a single hydrophilic polymeric component comprising one or more reactive groups,
wherein the matrix and the single hydrophilic polymeric component are associated with each other so that:
the reactivity of the single hydrophilic polymeric component is retained and
wherein the injury comprises a member selected from the group consisting of a wound, a hemorrhage, a damaged tissue, and a bleeding tissue.

16. The method of claim 15 , wherein the sponge is applied to the injury together with a buffer solution.

17. The method of claim 16 , wherein the buffer solution comprises a bicarbonate solution.

18. The method of claim 16 , wherein the buffer solution is present on a gauze.

19. The method of treating an injury of claim 15 , wherein the single hydrophilic polymeric crosslinker is coated onto a surface of the matrix.

20. The method of treating an injury of claim 15 , wherein the matrix is impregnated with the single hydrophilic polymeric crosslinker.

21. The method of treating an injury of claim 15 , wherein the matrix is impregnated with the single hydrophilic polymeric crosslinker, and wherein the single hydrophilic polymeric crosslinker is coated onto a surface of the matrix.

22. A kit, comprising:
a hemostatic porous composite sponge, comprising:
a matrix of a biomaterial; and
a single hydrophilic polymeric component comprising one or more reactive groups,
wherein the matrix and the single hydrophilic polymeric component are associated with each other so that:
the reactivity of the single hydrophilic polymeric component is retained,
a buffer solution; and
instructions for using the hemostatic porous composite sponge and the buffer solution.

23. The kit of claim 22 , wherein the buffer solution comprises an alkaline buffer solution.

24. The kit of claim 23 , wherein the alkaline buffer solution comprises a bicarbonate.

25. The kit of claim 22 , wherein the single hydrophilic polymeric crosslinker is coated onto a surface of the matrix.

26. The kit of claim 22 , wherein the matrix is impregnated with the single hydrophilic polymeric crosslinker.

27. The kit of claim 22 , wherein the matrix is impregnated with the single hydrophilic polymeric crosslinker, and wherein the single hydrophilic polymeric crosslinker is coated onto a surface of the matrix.

Assignees

• Baxter Int
• Baxter Healthcare Sa
• Baxter Healthcare Sa

Inventors

• Hedrich Hans Christian
• Hoefinghoff Joris

Classifications

• A61P17/02

  for treating wounds, ulcers, burns, scars, keloids, or the like · CPC title

• A61L15/425 Primary

  Porous materials, e.g. foams or sponges · CPC title

• A61L15/28

  Polysaccharides or their derivatives {(A61L15/225 takes precedence)} · CPC title

• A61L15/18

  containing inorganic materials · CPC title

• A61L15/26 Primary

  Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof {(A61L15/225 takes precedence)} · CPC title