Ophthalmic compositions with alkoxylated natural waxes

Patent metadata

Field	Value
Publication number	US-9375401-B2
Application number	US-201314377460-A
Country	US
Kind code	B2
Filing date	Jan 10, 2013
Priority date	Feb 24, 2012
Publication date	Jun 28, 2016
Grant date	Jun 28, 2016

Abstract

Ophthalmic compositions comprising 0.005 wt. % to 2.0 wt. % of alkoxylated natural waxes selected from the group consisting of alkoxylated lanolin and alkoxylated jojoba, and a method of treating a patient diagnosed with dry eye syndrome, or for cleaning and disinfecting contact lenses, with the ophthalmic compositions.

First claim

We claim:

1. An ophthalmic composition comprising 0.005 wt. % to 2.0 wt. % of alkoxylated natural waxes selected from the group consisting of alkoxylated lanolin and alkoxylated jojoba, and 0.002 wt. % to 0.2 wt. % hyaluronic acid or 0.05 wt. % to 0.3 wt. % hydroxypropyl guar, and having a pH of from 6 to 8.4.

2. The composition of claim 1 wherein the alkoxylated natural wax is alkoxylated lanolin.

3. The composition of claim 2 wherein the alkoxylated lanolin is PEG75 lanolin.

4. The composition of claim 1 wherein the alkoxylated natural wax is a poloxamer derivative of lanolin.

5. The composition of claim 1 wherein the alkoxylated natural wax is alkoxylated jojoba.

6. The composition of claim 5 wherein the alkoxylated jojoba is PEG150 jojoba.

7. The composition of claim 1 wherein the alkoxylated natural wax is a poloxamer derivative of jojoba.

8. The composition of claim 1 wherein the composition further comprises a pharmaceutical agent.

9. The composition of claim 1 wherein the composition has a pH of from 6 to 8.

10. A contact lens care solution comprising: 0.005 wt. % to 2.0 wt. % of alkoxylated natural waxes selected from the group consisting of alkoxylated lanolin and alkoxylated jojoba; 0.002 wt. % to 0.04 wt. % hyaluronic acid or 0.005 wt. % to 0.06 wt. % hydroxypropyl guar; and one or more antimicrobial components selected from the group consisting of poly(hexamethylene biguanide), which is present from 0.5 ppm to 1.5 ppm; α-[4-tris(2-hydroxyethyl)-ammonium chloride-2-butenyl]poly[1-dimethyl ammonium chloride-2-butenyl]-ω-tris(2-hydroxyethyl) ammonium chloride, which is present from 1 ppm to 10 ppm; and alexidine, which is present from 1 ppm to 4 ppm, and having a pH of from 6 to 8.4.

11. The lens care solution of claim 10 wherein the alkoxylated natural wax is alkoxylated lanolin.

12. The lens care solution of claim 10 wherein the alkoxylated natural wax is a poloxamer derivative of lanolin.

13. The lens care solution of claim 10 wherein the alkoxylated natural wax is alkoxylated jojoba.

14. The lens care solution of claim 10 wherein the alkoxylated natural wax is a poloxamer derivative of jojoba.

15. The lens care solution of claim 10 further comprising dexpanthenol, sorbitol, glycolic acid, propylene glycol, 2-amino-2-methyl-1,3-propanediol or any mixture thereof.

16. A contact lens care solution of claim 10 , for sensitive eyes, the composition comprising 0.5 ppm to 1.5 ppm of poly(hexamethylene biguanide).

17. The contact lens care solution of claim 16 further comprising α-[4-tris(2-hydroxyethyl)-ammonium chloride-2-butenyl]poly[1-dimethyl ammonium chloride-2-butenyl]-ω-tris(2-hydroxyethyl) ammonium chloride, which is present from 1 ppm to 10 ppm, or alexidine, which is present from 1 ppm to 4 ppm.

18. The contact lens care solution of claim 16 wherein the alkoxylated natural wax is a poloxamer derivative of jojoba or a poloxamer derivative of lanolin.

19. The contact lens care solution of claim 10 wherein the solution has a pH of from 6 to 8.

20. A method of treating a patient diagnosed with symptoms of dry eye, the method comprising instructing a patient to self administer one or more eye drops of an ophthalmic composition comprising 0.005 wt. % to 2.0 wt. % of alkoxylated natural waxes selected from the group consisting of alkoxylated lanolin and alkoxylated jojoba, and 0.002 wt. % to 0.2 wt. % hyaluronic acid or 0.05 wt. % to 0.3 wt. % hydroxypropyl guar, and having a pH of from 6 to 8.4.

Assignees

• Bausch & Lomb
• Bausch & Lomb

Inventors

• Xia Erning
• Fridman Krista

Classifications

• A61K9/08

  Solutions {(composition of solutions A61K47/00)} · CPC title

• A61K47/34

  Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers (A61K47/10 takes precedence) · CPC title

• A61K9/0048 Primary

  Eye, e.g. artificial tears · CPC title

• A61P27/04

  Artificial tears; Irrigation solutions · CPC title

• A61K47/36

  Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin · CPC title