Method of coating 3,4-dihydroxyphenylalanine-based (DOPA) coatings onto substrates for adhering metal from fluids onto the substrate

Patent metadata

Field	Value
Publication number	US-9371455-B2
Application number	US-201514638303-A
Country	US
Kind code	B2
Filing date	Mar 4, 2015
Priority date	Oct 19, 2006
Publication date	Jun 21, 2016
Grant date	Jun 21, 2016

Abstract

The present invention provides a surface-independent surface-modifying multifunctional biocoating and methods of application thereof. The method comprises contacting at least a portion of a substrate with an alkaline solution comprising a surface-modifying agent (SMA) such as dopamine so as to modify the substrate surface to include at least one reactive moiety. In another version of the invention, a secondary reactive moiety is applied to the SMA-treated substrate to yield a surface-modified substrate having a specific functionality.

First claim

We claim:

1. A method of reducing amounts of metal in a fluid comprising the steps of:
a) contacting at least a portion of a substrate with an alkaline, aqueous solution under oxidative conditions, the solution comprising a surface-modifying agent according to Formula I:

wherein each of R 1 , R 2 , R 3 , R 4 and R 5 is independently selected from the group consisting of a thiol, a primary amine, a secondary amine, a nitrile, an aldehyde, an imidazole, an azide, a halide, a polyhexamethylene dithiocarbonate, a hydrogen, a hydroxyl, a carboxylic acid, an aldehyde, a carboxylic ester or a carboxamide, provided at least one of R 1 , R 2 , R 3 , R 4 and R 5 is not a hydrogen atom;
wherein x ranges from 0 to 10 and wherein y ranges from 0 to 10, provided that x or y is at least 1; and
b) contacting the surface-modified substrate with a reactive moiety, wherein the reactive moiety reacts with and is bound to the surface-modified substrate forming a moiety-modified substrate
c) positioning the moiety-modified substrate in a fluid with metal,
whereby the moiety-modified substrate binds to at least a portion of the metal, thereby reducing the amounts of metal in the fluid.

2. The method of claim 1 wherein the reactive moiety is a metal.

Assignees

• Univ Northwestern

Inventors

• Messersmith Phillip B
• Lee Haeshin

Classifications

• C23C18/40

  using reducing agents · CPC title

• C23C18/2066

  Use of organic or inorganic compounds other than metals, e.g. activation, sensitisation with polymers · CPC title

• C23C18/1844

  with use of organic or inorganic compounds other than metals, first · CPC title

• B05D1/185

  applying monomolecular layers (B05D1/204 takes precedence) · CPC title

• A61L2420/00

  Materials or methods for coatings medical devices · CPC title