Trehalose derivatives and pharmaceutical compositions for treating neurodegenerative diseases

Patent metadata

Field	Value
Publication number	US-9371350-B2
Application number	US-201414509175-A
Country	US
Kind code	B2
Filing date	Oct 8, 2014
Priority date	Jul 22, 2008
Publication date	Jun 21, 2016
Grant date	Jun 21, 2016

Abstract

The invented inositol and trehalose derivatives, prepared by introducing multiple units of the guanidine group to the backbone molecules, show excellent blood-brain barrier permeability, and accordingly, it can be easily transported to the brain tissues and utilized for the treatment of neurodegenerative diseases such as Alzheimer's disease and Huntington's disease.

First claim

What is claimed are:

1. A trehalose compound of Formula (3) or a salt thereof:

wherein,
R is

 n being an integer in the range of 1 to 12; and
R 1 is hydrogen, R, alkyl or —COR′, R′ being hydrogen, alkyl, aminoalkyl, arylalkyl, cycloalkyl, heteroalkyl or a phosphor.

2. A pharmaceutical composition containing the compound according to claim 1 or a salt thereof as an active ingredient.

3. A method for treating a Huntington's disease, comprising administering the pharmaceutical composition of claim 2 to a subject in need thereof.

Assignees

• Postech Acad Ind Found
• Postech Foundation

Inventors

• Chung Sung-Kee
• Lee Woo Sirl
• Kim Boram
• Im Jungkyun
• Ghosh Subhash C

Classifications

• A61P25/28

  for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia · CPC title

• A61P25/14

  for treating abnormal movements, e.g. chorea, dyskinesia · CPC title

• C07H15/04

  attached to an oxygen atom of the saccharide radical · CPC title

• C07H3/04 Primary

  Disaccharides · CPC title

• A61K31/155

  Amidines ([IMAGE cpc-sch-A61K-1029.gif]), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2) · CPC title