System and method for optimized apheresis draw and return

Patent metadata

Field	Value
Publication number	US-9364600-B2
Application number	US-201414167267-A
Country	US
Kind code	B2
Filing date	Jan 29, 2014
Priority date	Apr 14, 2008
Publication date	Jun 14, 2016
Grant date	Jun 14, 2016

Abstract

A blood processing device includes a venous-access device, a blood component separation device, a return line, a draw line, a first pressure sensor, a second pressure sensor, and a first pump. The first pressure sensor is located on the return line between the blood component separation device and the venous-access device, and determines a first pressure. The second pressure sensor is located on the draw line between the blood component separation device and the venous-access device, and determines a second pressure. The first pump is connected to at least one of the return line and the draw line and controls a flow rate within the connected line based on a subject access pressure determined based upon the first and second pressures.

First claim

We claim:

1. A method of collecting and exchanging blood components using blood processing equipment comprising:
inserting a venous-access device into a subject, the venous-access device fluidly connected to a blood separation device;
withdrawing blood from the subject such that the drawn blood is collected in a the blood component separation device for processing;
separating the withdrawn blood into a first blood component and a second blood component using the blood component separation device;
extracting the second blood component from the blood component separation device;
returning the first blood component to the subject through a draw/return line;
measuring a first pressure within the draw/return line using a first pressure sensor, the first pressure sensor being located on the draw/return line between the venous-access device and the blood component separation device;
measuring a second pressure within the draw/return line using a second pressure sensor, the second pressure sensor being located on the draw/return line between the venous-access device and the first pressure sensor; and
controlling a flow rate within the draw/return fluid line based on a subject access pressure determined using the first pressure and the second pressure.

2. A method according to claim 1 further including introducing anticoagulant into the withdrawn blood through an anticoagulant line.

3. A method according to claim 1 , wherein the blood component separation device is a centrifuge bowl.

4. A method according to claim 1 , wherein the draw/return line includes a valve located between the blood component separation device and the venous-access device, the valve stopping the flow within the draw/return line.

5. A method according to claim 1 , wherein the subject access pressure is further determined using at least one characteristic of a first portion of the draw/return line and at least one characteristic of a second portion of the draw/return line, wherein the first portion is between the first and second pressure sensors and the second portion is between the second pressure sensor and the venous-access device.

6. A method according to claim 5 , wherein the at least one characteristic of the first portion of the draw/return line and the at least one characteristic of the second portion of the draw/return line are selected from the group consisting of length, inner diameter, and materials of construction.

7. A method according to claim 5 , wherein the flow rate is also controlled based on a first flow resistance within the first portion of the draw/return line, the first flow resistance calculated based on the at least one characteristic of the first portion of the draw/return line.

8. A method according to claim 5 , wherein the flow rate is further controlled based on a second flow resistance within the second portion of the draw/return line, the second flow resistance calculated based on the at least one characteristic of the second portion of the draw/return line.

9. A method according to claim 1 , wherein the blood component separation device further separates the drawn blood into a third blood component in addition to the first blood component and the second blood component.

10. A method according to claim 9 , wherein the first blood component is red blood cells, the second blood component is platelets, and the third blood component is plasma.

11. A method according to claim 1 , wherein the subject access pressure is determined in real-time.

12. A method according to claim 1 , wherein the flow rate is at least one of a draw flow rate and a return flow rate.

Assignees

• Haemonetics Corp

Inventors

• Pagès Etienne
• Ragusa Michael

Classifications

• A61M2205/3331

  Pressure; Flow · CPC title

• A61M2205/3344

  Measuring or controlling pressure at the body treatment site · CPC title

• A61M1/36

  Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation {; Extra-corporeal blood circuits} · CPC title

• A61M1/382

  Optimisation of blood component yield · CPC title

• A61M2205/3393

  by weighing the reservoir · CPC title