Anti-inflammatory actions of neuroprotectin D1/protectin D1 and its natural stereoisomers

Patent metadata

Field	Value
Publication number	US-9364454-B2
Application number	US-201213625865-A
Country	US
Kind code	B2
Filing date	Sep 24, 2012
Priority date	Oct 3, 2005
Publication date	Jun 14, 2016
Grant date	Jun 14, 2016

Abstract

The invention describes novel isolated, purified, 10,17-dihydroxy-docosahexaenoic acids, esters, derivatives and their preparation.

First claim

We claim:

1. A purified compound of formula (I), (III), (IV), (V), or (VIII):

wherein R is a hydrogen atom, an alkyl group, or a pharmaceutically acceptable salt; P 1 and P 2 are each, individually, a hydrogen atom or a protecting group and * indicates bonds are, independently, in the R or S configuration.

2. The compound of claim 1 , wherein when P 1 and P 2 are both hydrogen atoms, then R is other than a hydrogen atom.

3. The compound of claim 1 , wherein P 1 and P 2 are each hydrogen atoms and R is a hydrogen atom.

4. A composition comprising a compound of claim 1 , and a pharmaceutically acceptable carrier.

5. A method to treat airway inflammation comprising administration of a therapeutically acceptable amount of a compound of claim 1 .

6. The method of claim 5 , wherein P 1 and P 2 are each hydrogen atoms and R is a hydrogen atom.

7. The method of claim 5 , wherein said airway inflammation is asthma.

8. The method of claim 5 , wherein when P 1 and P 2 are both hydrogen atoms, then R is other than a hydrogen atom.

9. A method to treat airway inflammation comprising administration of a therapeutically acceptable amount of a composition of claim 4 .

10. The method of claim 9 , wherein P 1 and P 2 are each hydrogen atoms and R is a hydrogen atom.

11. The method of claim 9 , wherein said airway inflammation is asthma.

12. The method of claim 5 , wherein P 1 and P 2 are each hydrogen atoms and R is a hydrogen atom.

13. The method of claim 5 , wherein said airway inflammation is asthma.

Assignees

• Serhan Charles N
• Petasis Nicos A
• Levy Bruce D
• Brigham & Womens Hospital
• Univ Southern California

Inventors

• Serhan Charles N
• Petasis Nicos A
• Levy Bruce D

Classifications

• C07C59/42

  containing hydroxy or O-metal groups · CPC title

• C07C69/732

  of unsaturated hydroxy carboxylic acids · CPC title

• A61P11/06

  Antiasthmatics · CPC title

• A61K31/202 Primary

  having three or more double bonds, e.g. linolenic (eicosanoids, e.g. leukotrienes A61K31/557) · CPC title