Apparatus method and system for measuring strain in biological tissue

Patent metadata

Field	Value
Publication number	US-9364169-B2
Application number	US-201313769089-A
Country	US
Kind code	B2
Filing date	Feb 15, 2013
Priority date	Feb 15, 2012
Publication date	Jun 14, 2016
Grant date	Jun 14, 2016

Abstract

An apparatus for in-situ sensing of longitudinal and transverse strain in biological tissue (e.g. tendons and ligaments) includes a set of sensing electrodes that contact biological tissue and enable measurement of an electrical property of the biological tissue along two or more directions. The apparatus may also include a sensing module that senses the electrical property of the biological tissue along the two or more directions to provide multi-directional measurements that are captured by a logging module. The apparatus may also include a transmission module that transmits the captured measurements to a data analysis workstation or the like. The data analysis workstation may include a strain estimation module that receives the multi-directional measurement and estimates a longitudinal strain and a transverse strain therefrom. A corresponding system and method for in-situ sensing of longitudinal and transverse strain in biological tissue is also presented.

First claim

What is claimed is:

1. An apparatus comprising:
a plurality of sensing electrodes that are electrically conductive and configured to contact subcutaneous biological tissue, the plurality of sensing electrodes configured to measure an electrical property of the biological tissue along at least a first direction defined between a first pair of the plurality of sensing electrodes and a second direction defined between a second pair of the plurality of sensing electrodes, the first pair being different from the second pair;
at least one processor; and
a memory storing instructions that, when executed by the at least one processor, causes the apparatus to:
determine a longitudinal component of the electrical property that corresponds to a direction that is substantially parallel to a primary direction of collagen fibers in the biological tissue and a transverse component of the electrical property that corresponds to a direction that is substantially perpendicular to the primary direction of collagen fibers in the biological tissue using the measured electrical property along the first direction and the measured electrical property along the second direction, and
estimate a longitudinal strain in the biological tissue as a function of the longitudinal component and estimate a transverse strain in the biological tissue as a function of the transverse component.

2. The apparatus of claim 1 , wherein the electrical property is at least one of electrical resistance, electrical potential and electrical current.

3. The apparatus of claim 1 , wherein the plurality of sensing electrodes enable measurement of the electrical property along a third direction defined between a third pair of electrodes, the third pair being different from the first pair and the second pair.

4. The apparatus of claim 1 , wherein the plurality o f sensing electrodes electrically connect the biological tissue as a resistive component of a sensing circuit.

5. The apparatus of claim 4 , wherein the sensing circuit is a wheatstone bridge.

6. The apparatus of claim 1 , further comprising a transmitter for transmitting the multi-directional measurement of the electrical property.

7. The apparatus of claim 6 , wherein the transmitter comprises a wireless transmitter.

8. A method comprising:
providing a biological tissue strain sensing device comprising a plurality of sensing electrodes that are electrically conductive and configured to contact biological tissue and to measure an electrical property of the biological tissue in at least a first direction defined between a first pair of the plurality of sensing electrodes and a second direction defined between a second pair of the plurality of sensing electrodes, the first pair being different from the second pair, and a sensing module electrically connected to the plurality of sensing electrodes and configured to sense the electrical property of the biological tissue along the first direction and along the second direction via the plurality of sensing electrodes;
measuring the electrical property of the biological tissue that corresponds to electrical resistance along the first direction and along the second direction to provide a multi- directional measurement of the electrical property;
determining a longitudinal component of the electrical property, wherein the longitudinal component corresponds to a primary direction of collagen fibers in the biological tissue;
determining a transverse component of the electrical property, wherein the transverse component corresponds to a direction that is substantially perpendicular to the primary direction of collagen fibers in the biological tissue; and
estimating a longitudinal strain in the biological tissue and a transverse strain in the biological tissue from the multi-directional measurement, the longitudinal strain being a function of the longitudinal component and the transverse strain being a function of the transverse component.

9. The method of claim 8 , further comprising:
repeating the measuring to provide a plurality of multi-directional measurements; and
logging the plurality of multi-directional measurements to provide captured measurements.

10. The method of claim 9 , further comprising reading the captured measurements.

11. The method of claim 9 , further comprising transmitting the captured measurements.

12. The method of claim 9 , wherein the captured measurements correspond to a selected sample rate.

13. The method of claim 8 , wherein the electrical property is at least one of electrical resistance, electrical current and electrical potential.

14. The method of claim 8 , further comprising penetrating through a layer of skin with the electrodes of the biological tissue strain sensing device to measure the electrical properties of the biological tissue.

15. The method of claim 8 , the biological tissue being connected as a resistive component of a sensing circuit within the sensing module.

16. The method of claim 8 , wherein the function is a linear function.

17. A system comprising:
a plurality of sensing electrodes that are electrically conductive and configured to contact biological tissue and to measure an electrical property of the biological tissue that corresponds to electrical resistance in at least a first direction defined between a first pair of the plurality of sensing electrodes and a second direction defined between a second pair of the plurality of sensing electrodes, the first pair being different from the second pair,
a wireless transmitter configured to transmit the measured electrical property of the biological tissue in the first direction and the measured electrical property of the biological tissue in the second direction as a multi-directional measurement; and
a workstation configured to receive the multi-directional measurement from the wireless transmitter and estimate a longitudinal strain in the biological tissue in a direction substantially parallel to a primary direction of collagen fibers in the biological tissue and a transverse strain in the biological tissue as a function of the multi-directional measurement.

Assignees

• Univ Brigham Young

Inventors

• West Christopher R
• Bowden Anton E

Classifications

• A61B5/1126 Primary

  using a particular sensing technique · CPC title

• A61B5/4523

  Tendons · CPC title

• A61B5/0538

  invasively, e.g. using a catheter · CPC title

• A61B5/4533

  Ligaments · CPC title

• A61B5/0004

  characterised by the type of physiological signal transmitted · CPC title