Intestinal environment-improving agent

Patent metadata

Field	Value
Publication number	US-9364017-B2
Application number	US-201314395743-A
Country	US
Kind code	B2
Filing date	Feb 19, 2013
Priority date	Apr 26, 2012
Publication date	Jun 14, 2016
Grant date	Jun 14, 2016

Abstract

An intestinal environment-improving agent containing, as an effective component, a starch with a high resistant starch content that satisfies the following conditions (a), (b), (c), and (d):
(a) a content of a resistant starch measured by the resistant starch measurement method of AOAC official method 2002. 02 is equal to or higher than 60%; (b) a peak of a molecular weight is equal to or higher than 6×10 3 and equal to or lower than 4×10 4 ; (c) a molecular weight dispersity is equal to or higher than 1.5 and equal to or higher than 6.0; and (d) a gelatinization enthalpy at 50° C. to 130° C. measured by a differential scanning calorimetry is equal to or lower than 10 J/g.

First claim

The invention claimed is:

1. An intestinal environment-improving agent comprising, as an effective component, a starch with a high resistant starch content that satisfies the following conditions (a), (b), (c), and (d):
(a) a content of a resistant starch measured by the resistant starch measurement method of AOAC official method 2002. 02 is equal to or higher than 60%;
(b) a peak molecular weight measured using HPLC unit with a calibration curve prepared using pullulan is equal to or higher than 6×10 3 and equal to or lower than 4×10 4 ;
(c) a molecular weight dispersity is equal to or higher than 1.5 and equal to or lower than 6.0; and
(d) a gelatinization enthalpy at 50° C. to 130° C. measured by a differential scanning calorimetry is equal to or lower than 10 J/g.

2. The intestinal environment-improving agent according to claim 1 ,
wherein the starch with a high resistant starch content is obtainable by using a starch with a high amylose content that has an amylose content of equal to or higher than 40% as a raw material and treating the raw material with an acid in an aqueous inorganic acid solution.

3. The intestinal environment-improving agent according to claim 1 that has a function of increasing the number of enteric bacteria belonging to the genus Bifidobacterium.

4. The intestinal environment-improving agent according to claim 1 that has a lipid metabolism-improving function.

5. The intestinal environment-improving agent according to claim 4 ,
wherein the lipid metabolism-improving function is a function of decreasing a total cholesterol level in blood.

6. The intestinal environment-improving agent according to claim 4 ,
wherein the lipid metabolism-improving function is a function of decreasing levels of triglyceride in blood.

7. The intestinal environment-improving agent according to claim 4 ,
wherein the lipid metabolism-improving function is a function of decreasing an arteriosclerotic index represented by the following Formula (I):
arteriosclerotic index=((total cholesterol concentration (mg/dl))−(HDL cholesterol concentration (mg/dl)))/(HDL cholesterol concentration (mg/dl))  (I).

8. The intestinal environment-improving agent according to claim 4 , further comprising an insoluble dietary fiber.

9. The intestinal environment-improving agent according to claim 8 ,
wherein the insoluble dietary fiber is a cellulose or a cellulose derivative.

10. The intestinal environment-improving agent according to claim 9 ,
wherein the insoluble dietary fiber is cellulose.

11. Drink or food comprising the intestinal environment-improving agent according to claim 1 .

12. A feed comprising the intestinal environment-improving agent according to claim 1 .

Assignees

• J Oil Mills Inc

Inventors

• Nagahata Yuya
• Kobayashi Isao
• Goto Masaru

Classifications

• A61P9/10

  for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis · CPC title

• A61P43/00

  Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title

• A61P3/06

  Antihyperlipidemics · CPC title

• A23L33/21

  Addition of substantially indigestible substances, e.g. dietary fibres · CPC title

• A61K31/718 Primary

  Starch or degraded starch, e.g. amylose, amylopectin · CPC title