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Cell line, system and method for optical-based screening of ion-channel modulators
US9360472B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9360472-B2 |
| Application number | US-201313850436-A |
| Country | US |
| Kind code | B2 |
| Filing date | Mar 26, 2013 |
| Priority date | Jul 22, 2005 |
| Publication date | Jun 7, 2016 |
| Grant date | Jun 7, 2016 |
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Abstract
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A variety of applications, systems, methods and constructs are implemented for use in connection with screening of ion-channel modulators. Consistent with one such system, drug candidates are screened to identify their effects on cell membrane ion channels and pumps. The system includes screening cells having light responsive membrane ion switches, voltage-gated ion switches and fluorescence producing voltage sensors. A chemical delivery device introduces the drug candidates to be screened. An optical delivery device activates the light responsive ion switches. An optical sensor monitors fluorescence produced by the voltage sensors. A processor processes data received from the optical sensor. A memory stores the data received from the optical sensor.
First claim
Opening claim text (preview).
What is claimed is: 1. A system for screening drug candidates to identify their effects on a cell membrane voltage-gated ion channel, the system comprising: a) a recombinant mammalian cell genetically modified to express a light responsive ChR2 ion channel comprising an amino acid sequence having at least 75% amino acid sequence identity to SEQ ID NO:1 and a heterologous microbial light-responsive ion pump, wherein the cell comprises a voltage-gated ion channel and a fluorescence…
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Operations & Transport · mapped topic
Operations & Transport · mapped topic
Chemistry & Metallurgy · mapped topic
Physics · mapped topic
- G01N33/502Primary
Physics · mapped topic
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- What does patent US9360472B2 cover?
- A variety of applications, systems, methods and constructs are implemented for use in connection with screening of ion-channel modulators. Consistent with one such system, drug candidates are screened to identify their effects on cell membrane ion channels and pumps. The system includes screening cells having light responsive membrane ion switches, voltage-gated ion switches and fluorescence pr…
- Who is the assignee on this patent?
- Univ Leland Stanford Junior
- What technology area does this patent fall under?
- Primary CPC classification G01N33/502. Mapped technology areas include Physics.
- When was this patent published?
- Publication date Tue Jun 07 2016 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).