Bio-implantable devices having super-hydrophobic surface and method for manufacturing thereof

Patent metadata

Field	Value
Publication number	US-9358093-B2
Application number	US-201213713414-A
Country	US
Kind code	B2
Filing date	Dec 13, 2012
Priority date	Jul 4, 2012
Publication date	Jun 7, 2016
Grant date	Jun 7, 2016

Abstract

The present disclosure relates to a bioimplantable device having a superhydrophobic surface and a method for manufacturing the same. The bioimplantable device, which includes a biocompatible substrate and a superhydrophobic nanostructure formed on the surface of the biocompatible substrate, is capable of preventing blood clot formation by blocking contact with proteins, water, blood platelets, etc. when used for blood vessels.

First claim

What is claimed is:

1. A method for manufacturing an anti-thrombogenic bioimplantable device having a superhydrophobic surface, comprising:
forming a nanoporous metal oxide film on the surface of a biocompatible substrate;
forming a nanostructure on the biocompatible substrate by subjecting the biocompatible substrate having the nanoporous metal oxide film formed to a temperature of 60-250° C. and the pressure of 0.01-0.5 Mpa;
removing the nanoporous metal oxide film remaining on the portion where the nanostructure is not formed by treating the biocompatible substrate having the nanostructure formed with a metal oxide film removing solution; and
washing the biocompatible substrate having the nanoporous metal oxide film removed with alcohol and distilled water and then drying,
wherein before said forming the nanoporous metal oxide film, applying one or more solvent selected from a group consisting of chloroform, acetone, tetrahydrofuran, toluene, xylene and dioxane on the surface of the biocompatible substrate.

2. The method for manufacturing an anti-thrombogenic bioimplantable device having a superhydrophobic surface according to claim 1 , wherein the solvent is applied on the surface of the biocompatible substrate in an amount of 1-1000 μL per 10 mm 2 .

3. The method for manufacturing an anti-thrombogenic bioimplantable device having a superhydrophobic surface according to claim 1 , wherein, in said forming the nanoporous metal oxide film, the biocompatible substrate is a biocompatible polymer film or a metal wire coated with a biocompatible polymer.

4. The method for manufacturing an anti-thrombogenic bioimplantable device having a superhydrophobic surface according to claim 1 , wherein, in said forming the nanoporous metal oxide film, the biocompatible substrate comprises a polymer selected from a group consisting of polylactide, polycaprolactone, polyglycolide, polypropylene, polyethylene, polyvinyl chloride, polybutadiene, poly(methyl methacrylate), poly(acrylic acid), poly(2-hydroxyethlymethacrylate), polycarbonate, poly(ethylene terephthalate), polyurethane and blends or copolymers thereof.

5. The method for manufacturing an anti-thrombogenic bioimplantable device having a superhydrophobic surface according to claim 3 , wherein the metal wire comprises one selected from a group consisting of aluminum, stainless steel, iron, nickel, copper, silver, gold, titanium, zirconium and alloys thereof.

6. The method for manufacturing an anti-thrombogenic bioimplantable device having a superhydrophobic surface according to claim 1 , wherein, in said forming the nanoporous metal oxide film, the nanoporous metal oxide film has pores with an average diameter of 20-500 nm.

7. The method for manufacturing an anti-thrombogenic bioimplantable device having a superhydrophobic surface according to claim 1 , wherein, in said forming the nanoporous metal oxide film, the nanoporous metal oxide film comprises anodized aluminum oxide or magnesium oxide.

8. The method for manufacturing an anti-thrombogenic bioimplantable device having a superhydrophobic surface according to claim 1 , wherein, in said removing the nanoporous metal oxide film remaining on the portion where the nanostructure is not formed, the metal oxide film removing solution is one selected from a group consisting of an aqueous hydrogen peroxide (H 2 O 2 ) solution, an aqueous sodium hydroxide (NaOH) solution, an aqueous potassium hydroxide (KOH) solution and mixture solutions thereof.

Assignees

• Korea Inst Sci & Tech

Inventors

• Kim Soo Hyun
• Lim Jin Ik
• Jung Youngmee

Classifications

• A61L33/022

  Metal or alloys · CPC title

• A61L2400/12

  Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces · CPC title

• A61P7/02

  Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors · CPC title

• A61F2/01 Primary

  Filters implantable into blood vessels · CPC title

• C08L101/16

  the macromolecular compounds being biodegradable · CPC title