Difluorocarbene radiosynthesis
US-2024383827-A1 · Nov 21, 2024 · US
US9357780B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9357780-B2 |
| Application number | US-201414454866-A |
| Country | US |
| Kind code | B2 |
| Filing date | Aug 8, 2014 |
| Priority date | May 5, 2009 |
| Publication date | Jun 7, 2016 |
| Grant date | Jun 7, 2016 |
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This document discloses molecules having the following formula (“Formula I”):
Opening claim text (preview).
We claim: 1. A process comprising; in step a, treating a compound of Formula XVIIb (where R4 is H) with BOC-anhydride in the presence of a base in a polar aprotic solvent to yield a compound of Formula XXV (where R4 is H), and then in step b, reacting a compound of Formula XXV with a boronic acid of Formula XIXc under Suzuki coupling conditions to provide a compound of Formula XXVI (where R4 is H), and then in step c, treating a compound of Formula XXVI with an electrophilic source of halogen to yield a compound of Formula XXVII (where R4 is F, Cl, Br, or I), wherein: X is N or CR8; R1 is H; R2 is H; R3 is H; R8 is H, or F; and n is 0, 1, or 2.
Non condensed pyridines; Hydrogenated derivatives thereof · CPC title
containing the group >N—CO—N< where at least one nitrogen atom is part of a heterocyclic ring; Thio analogues thereof · CPC title
directly linked by a ring-member-to-ring-member bond · CPC title
1,3-Thiazoles; Hydrogenated 1,3-thiazoles · CPC title
containing three or more hetero rings · CPC title
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