Detector array with time-to-digital conversion having improved temporal accuracy

Patent metadata

Field	Value
Publication number	US-9354332-B2
Application number	US-201214009666-A
Country	US
Kind code	B2
Filing date	Mar 29, 2012
Priority date	Apr 5, 2011
Publication date	May 31, 2016
Grant date	May 31, 2016

Abstract

A detector ( 22 ) detects an event. First and second time-to-digital converters (TDCs) ( 70, 72 ) generate first and second time stamps (TS 1 , TS 2 ) for the detection of the event. The first TDC and the second TDC are both synchronized with a common clock signal ( 62 ) that defines a fixed time offset between the second TDC and the first TDC. An autocalibration circuit ( 120 ) adjusts the first TDC and the second TDC to keep the time difference between the second time stamp and the first time stamp equal to the fixed time offset between the second TDC and the first TDC. The detector may be a detector array, and trigger circuitry ( 28 ) propogates a trigger signal from a trigger detector of the array of detectors to the first and second TDC's. Skew correction circuitry ( 132, 134, 136, 142, 60, 162 ) adjusts a timestamp (TS) based on which detector is the triggering detector.

First claim

Having described the preferred embodiments, the invention is now claimed to be:

1. A method comprising:
(i) synchronizing a first time-to-digital converter (TDC) with a common clock signal;
(ii) synchronizing a second TDC with the common clock signal wherein the synchronizing operations (i) and (ii) determine a fixed time offset of the second TDC respective to the first TDC as the period of the common clock signal or as a fixed fraction or multiple of the period of the common clock signal;
detecting an event;
generating a trigger signal associated with the detection of the event;
generating a first time stamp for the trigger signal by measuring a first time interval using the first TDC and transforming the first time interval into the first time stamp using a first transform operation including multiplying by a multiplication factor;
generating a second time stamp for the trigger signal by measuring a second time interval using the second TDC and transforming the second time interval into the second time stamp using a second transform operation including multiplying by the multiplication factor;
associating a time stamp with the event based on the first time stamp and the second time stamp; and
increasing or decreasing the multiplication factor to reduce any difference between (1) the time difference between the second time stamp and the first time stamp and (2) the fixed time offset.

2. The method of claim 1 , wherein the increasing or decreasing comprises:
increasing the multiplication factor if the time difference between the second time stamp and the first time stamp is smaller than the fixed time offset; and
decreasing the multiplication factor if the time difference between the second time stamp and the first time stamp is larger than the fixed time offset.

3. The method of claim 1 , wherein the first transform operation includes applying a first look-up table and the second transform operation includes applying a second look-up table.

4. The method of claim 1 , wherein the detecting is performed using an array of detectors, the trigger signal is generated by a triggering detector of the array of detectors, and the method further comprises:
delaying the trigger signal by a delay time selected based on the triggering detector.

5. The method of claim 4 , wherein the delaying comprises:
providing tunable delay elements in a trigger signal network associated with the array of detectors; and
setting delay times for the tunable delay elements to compensate skew of the array of array of detectors.

6. The method of claim 1 , wherein the detecting is performed using an array of detectors, the trigger signal is generated by a triggering detector of the array of detectors, and the method further comprises:
adjusting the first time stamp and the second time stamp based on the triggering detector.

7. The method of claim 1 , wherein the associating comprises:
associating the event with one of (i) the first time stamp, (ii) the second time stamp, and (iii) an aggregation of the first time stamp and the second time stamp;
wherein the associating selects between (i), (ii), and (iii) based on an assessment of reliability of the first time stamp and of the second time stamp.

8. The method of claim 1 , wherein the detecting comprises detecting a radiation particle using an array of positron emission tomography (PET) detectors, and the method further comprises:
repeating the detecting, generating of the trigger signal, generating of first and second time stamps, and associating to acquire a data set of time stamped radiation detection events;
generating a time-of-flight (TOF) PET data set from the data set of time stamped radiation detection events; and
reconstructing the TOF PET data set to generate a PET image.

9. An apparatus comprising:
a detector configured to detect an event;
a first time-to-digital converter (TDC) configured to generate a first time stamp for the detection of the event by measuring a first time interval and transforming the first time interval into the first time stamp using a first transform operation including multiplying by a multiplication factor;
a second TDC configured to generate a second time stamp for the detection of the event by measuring a second time interval and transforming the second time interval into the second time stamp using a second transform operation including multiplying by the multiplication factor, there being a fixed time offset between the second TDC and the first TDC; and
an autocalibration circuit configured to adjust the multiplication factor to keep the time difference between the second time stamp and the first time stamp equal to the fixed time offset between the second TDC and the first TDC.

10. The apparatus of claim 9 , wherein:
the first TDC and the second TDC are both synchronized with a common clock signal that defines the fixed time offset between the second TDC and the first TDC as the period of the common clock signal or as a fixed fraction or multiple of the period of the common clock signal.

11. The apparatus of claim 9 , wherein the autocalibration unit is configured to increase the multiplication factor if the time difference between the second time stamp and the first time stamp is smaller than the fixed time offset and to decrease the multiplication factor if the time difference between the second time stamp and the first time stamp is larger than the fixed time offset.

12. The apparatus of claim 9 , wherein the first transform operation further includes applying a first look-up table and the second transform operation further includes applying a second look-up table.

13. The apparatus of claim 9 , wherein the detector comprises an array of detectors and the apparatus further comprises:
trigger circuitry configured to propagate a trigger signal associated with the detection of the event from a triggering detector of the array of detectors to the first and second TDC's, the trigger circuitry including delay elements configured to delay propagation of the trigger signal based on which detector is the triggering detector.

14. The apparatus of claim 9 , wherein the detector comprises an array of detectors and the apparatus further comprises:
trigger circuitry configured to propagate a trigger signal associated with the detection of the event from a triggering detector of the array of detectors to the first and second TDC's; and
skew correction circuitry configured to adjust a timestamp generated from the first timestamp and the second timestamp based on which detector is the triggering detector.

15. The apparatus of claim 9 , wherein the detector comprises an array of silicon-based single photon avalanche detector (SPAD) cells.

16. A positron emission tomography (PET) system including:
radiation detectors comprising the apparatus of claim 9 ; and
a processing device configured to generate time-of-flight (TOF) PET data from the output of the radiation detectors and to reconstruct the TOF PET data to generate an image.

17. An apparatus comprising:
an array of detectors configured to detect an event;
trigger circuitry configured to propagate a trigger signal associated with the detection of the event from a triggering detector of the array of detectors to time stamp circuitry configured to generate a digital time stamp for the detection of the event using a time-to-digital converter (TDC);
a set of row flip-flops and a set of column flip-flops at the periphery of the array of detectors that store the (row, column) index of the triggering detector of the array of detectors;
skew co

Assignees

• Zwaans Bernardus Antonius Maria
• Frach Thomas
• Koninkl Philips Nv

Inventors

• Zwaans Bernardus Antonius Maria
• Frach Thomas

Classifications

• G01T1/2985 Primary

  In depth localisation, e.g. using positron emitters; Tomographic imaging (longitudinal and transverse section imaging; apparatus for radiation diagnosis sequentially in different planes, steroscopic radiation diagnosis); (using external radiation sources A61B6/02) · CPC title

• G04F10/005

  Time-to-digital converters [TDC] (analog-to-digital converters with intermediate conversion to time or phase H03M1/50, H03M1/60) · CPC title

• A61B6/037

  Emission tomography · CPC title