Method for the purification of prostaglandins
US-8957240-B2 · Feb 17, 2015 · US
Method for the purification of prostaglandins
US9353055B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9353055-B2 |
| Application number | US-201514594668-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jan 12, 2015 |
| Priority date | Jun 22, 2009 |
| Publication date | May 31, 2016 |
| Grant date | May 31, 2016 |
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- Title
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Abstract
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The present invention provides a method for the purification of a prostaglandin by supercritical fluid chromatography, said method comprising the use of a stationary phase and a mobile phase comprising carbon dioxide, provided that when the stationary phase is unmodified silica gel, the prostaglandin is not luprostiol. The invention also provides prostaglandins obtainable by the method.
First claim
Opening claim text (preview).
What is claimed: 1. A latanoprost composition comprising C11-beta isomer of latanoprost in an amount greater than 0% and less than 0.03%, and containing less than 0.03% C15R-Trans isomer of latanoprost, less than 0.05% C15S-Trans isomer of latanoprost, and less than 0.03% C15S-Cis isomer of latanoprost, after 11 months storage at freezer temperature. 2. A latanoprost composition comprising a C11-beta isomer of latanoprost in an amount greater than 0% and less than 0.03%, after 11 months storage at freezer temperature.
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Classifications
condensed with a ring other than six-membered · CPC title
with hydrocarbon or substituted hydrocarbon radicals directly attached in position 2, e.g. prostacyclins · CPC title
of unsaturated hydroxy carboxylic acids · CPC title
Benz[f]indenes; Hydrogenated benz[f]indenes · CPC title
- C07C405/00Primary
Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins {; Analogues or derivatives thereof} · CPC title
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- What does patent US9353055B2 cover?
- The present invention provides a method for the purification of a prostaglandin by supercritical fluid chromatography, said method comprising the use of a stationary phase and a mobile phase comprising carbon dioxide, provided that when the stationary phase is unmodified silica gel, the prostaglandin is not luprostiol. The invention also provides prostaglandins obtainable by the method.
- Who is the assignee on this patent?
- Johnson Matthey Plc
- What technology area does this patent fall under?
- Primary CPC classification C07C405/00. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue May 31 2016 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 1 related publication on this page (citations in our corpus or others sharing the same primary CPC).