Methods and systems for treating a psychotic disorder

Patent metadata

Field	Value
Publication number	US-9352145-B2
Application number	US-49738609-A
Country	US
Kind code	B2
Filing date	Jul 2, 2009
Priority date	Dec 22, 2004
Publication date	May 31, 2016
Grant date	May 31, 2016

Abstract

Methods of treating a psychotic disorder include applying at least one stimulus to a stimulation site within a patient with an implanted stimulator in accordance with one or more stimulation parameters configured to treat the psychotic disorder. Systems for treating a psychotic disorder include a stimulator configured to apply at least one stimulus to a stimulation site within a patient in accordance with one or more stimulation parameters configured to treat the psychotic disorder.

First claim

What is claimed is:

1. A method of treating a psychotic disorder comprising at least one of schizophrenia, a delusional disorder, a schizoaffective disorder, said method comprising:
applying at least one stimulus to a stimulation site within a patient with an implanted stimulator in accordance with one or more stimulation parameters to treat said psychotic disorder; and
sensing at least one indicator related to said psychotic disorder and using said at least one sensed indicator to adjust one or more of said stimulation parameters;
wherein said stimulation site comprises at least one or more of a frontal lobe, temporal lobe, cingulate gyrus, substantia nigra, thalamus, amygdala, hippocampus, ventral tegmental area, nucleus accumbens, and locus coeruleus; and
wherein said at least one indicator comprises a change in cerebrospinal fluid.

2. The method of claim 1 , wherein applying the at least one stimulus to the stimulation site within the patient with the implanted stimulator comprises delivering a stimulation current via one or more electrodes coupled to the implanted stimulator.

3. The method of claim 1 , wherein applying the at least one stimulus to the stimulation site within the patient with the implanted stimulator comprises a decreased activity of said stimulation site to treat said psychotic disorder.

4. The method of claim 1 , wherein applying the at least one stimulus to the stimulation site within the patient with the implanted stimulator comprises an increased activity of said stimulation site to treat said psychotic disorder.

5. The method of claim 1 , wherein the stimulus comprises at least one of an electrical stimulation, a drug stimulation, a gene infusion, a chemical stimulation, a thermal stimulation, an electromagnetic stimulation, and a mechanical stimulation.

6. The method of claim 1 , further comprising implanting the implanted stimulator at the stimulation site.

7. The method of claim 6 , wherein applying the at least one stimulus to the stimulation site within the patient with the implanted stimulator comprises delivering a stimulation current via one or more electrodes coupled to the implanted stimulator, and implanting the implanted stimulator comprises implanting the one or more electrodes in communication with the stimulation site.

8. A method of treating a psychotic disorder comprising at least one of schizophrenia, a delusional disorder, a schizoaffective disorder, said method comprising:
applying at least one stimulus to a stimulation site within a patient with an implanted stimulator in accordance with one or more stimulation parameters to treat said psychotic disorder; and
sensing at least one indicator related to said psychotic disorder and using said at least one sensed indicator to adjust one or more of said stimulation parameters;
wherein said stimulation site comprises at least one or more of a frontal lobe, temporal lobe, cingulate gyrus, substantia nigra, thalamus, amygdala, hippocampus, ventral tegmental area, nucleus accumbens, and locus coeruleus; and
wherein said at least one indicator comprises at least one of an interleukin level, a cytokine level, a lymphokine level, a chemokine level, a growth factor level, an electrolyte level, and an enzyme level.

9. The method of claim 8 , wherein applying the at least one stimulus to the stimulation site within the patient with the implanted stimulator comprises delivering a stimulation current via one or more electrodes coupled to the implanted stimulator, and further comprising implanting the one or more electrodes in communication with the stimulation site.

10. The method of claim 8 , further comprising implanting the implanted stimulator at the stimulation site.

11. The method of claim 8 , wherein said stimulus comprises one or more drugs delivered to said stimulation site.

12. The method of claim 8 , wherein said stimulus comprises a stimulation current delivered to said stimulation site and one or more drugs delivered to said stimulation site.

Assignees

• Whitehurst Todd K
• Jaax Kristen N
• Boston Scient Neuromodulation

Inventors

• Whitehurst Todd K
• Jaax Kristen N

Classifications

• A61N1/36082

  Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease · CPC title

• A61N1/3756

  Casings with electrodes thereon, e.g. leadless stimulators · CPC title

• A61N1/0531 Primary

  Brain cortex electrodes · CPC title

• A61N1/37205

  Microstimulators, e.g. implantable through a cannula · CPC title

• A61N1/0534

  Electrodes for deep brain stimulation · CPC title