Respiratory drug delivery apparatus including a feedback and compliance device

Patent metadata

Field	Value
Publication number	US-9352107-B2
Application number	US-201013520970-A
Country	US
Kind code	B2
Filing date	Dec 7, 2010
Priority date	Jan 7, 2010
Publication date	May 31, 2016
Grant date	May 31, 2016

Abstract

A respiratory drug delivery apparatus ( 2 ) includes a medication storage and delivery device ( 8 ) having an outlet ( 30 ) and a feedback and compliance device ( 32 ) coupled thereto. The feedback and compliance device has an opening, and the outlet of the medication storage and delivery device is received through the opening. The feedback and compliance device includes: (i) one or more sensors ( 46, 52, 54, 56 ), each of the one or more sensors being structured to sense a parameter relating to use of the respiratory drug delivery apparatus without modifying or interfering with a flow of medication introduced by actuation of the medication storage and delivery device, (ii) one or more feedback devices ( 48, 50, 62 ), and (iii) a processing unit ( 42 ) programmed to cause the one or more feedback devices to provide feedback information to a patient ( 4 ) regarding use of the respiratory drug delivery apparatus based on an output of at least one of the one or more sensors.

First claim

The invention claimed is:

1. A respiratory drug delivery apparatus, comprising:
a medication storage and delivery device having an outlet, the medication storage and delivery device being a metered dose inhaler having a canister received in a boot, the outlet being part of the boot; and
a feedback and compliance device coupled to the medication storage and delivery device, and coupled to a valved holding chamber, wherein the valved holding chamber includes a main chamber, an adapter coupled to the main chamber, and an exhalation valve, and wherein:
the feedback and compliance device is structured to be removable attached to the adapter via a connector extending from the feedback and compliance device, the connector being structured to be received and held within a slot provided in the adapter;
the adapter receives and holds the outlet of the boot of the metered dose inhaler, wherein the feedback and compliance device is held and positioned between a portion of the metered dose inhaler and the adapter; and
the feedback and compliance device has an opening, the outlet of the medication storage and delivery device being received through the opening, the feedback and compliance device including:
(i) one or more sensors, individual ones of the one or more sensors being structured to sense a parameter relating to use of the respiratory drug delivery apparatus without modifying or interfering with a flow of medication introduced by actuation of the medication storage and delivery device, wherein the one or more sensors include an infra-red sensor for sensing air temperature moving through the exhalation valve, and an infra-red sensor for sensing a position of the respiratory drug delivery apparatus relative to a face of a patient;
(ii) one or more feedback devices, and
(iii) a processing unit programmed to cause the one or more feedback devices to provide feedback information to a patient regarding use of the respiratory drug delivery apparatus based on an output of at least one of the one or more sensors, wherein the processing unit is programmed to cause the one or more feedback devices to provide feedback information in the form of audible instructions.

2. The respiratory drug delivery apparatus according to claim 1 , wherein the feedback information is, visual, or tactile, or a combination thereof.

3. The respiratory drug delivery apparatus according to claim 1 , wherein the one or more sensors include one or more of (i) a motion sensing device for sensing shaking of the medication storage and delivery device, (ii) a flow sensor for sensing inhalation by the patient, or (iii) a force sensing device for sensing actuation of the medication storage and delivery device.

4. The respiratory drug delivery apparatus according to claim 3 , wherein the motion sensing device is an accelerometer, wherein the flow sensor is a micro-electro-mechanical system flow sensor, and wherein the force sensing device is a load cell or a strain gauge.

5. The respiratory drug delivery apparatus according to claim 3 , wherein the processing unit is programmed to cause the one or more feedback devices to provide feedback information in the form of: (i) an instruction to shake the medication storage and delivery device in response to determining that the medication storage and delivery device has been inserted into the feedback and compliance device, (ii) an instruction to actuate the medication storage and delivery device in response to determining that the medication storage and delivery device has been shaken, (iii) an instruction to inhale in a first particular manner in response to determining that the medication storage and delivery device has been actuated, and (iv) an instruction whereby the patient is instructed to hold his or her breath in a second particular manner in response to determining that inhalation in the first particular manner has been completed.

6. The respiratory drug delivery apparatus according to claim 3 , wherein the processing unit is programmed to cause the one or more feedback devices to provide feedback information in the form of: (i) a first indication indicating that the medication storage and delivery device has been properly inserted into the feedback and compliance device in response to determining that the medication storage and delivery device has been inserted into the feedback and compliance device, (ii) a second indication indicating that the medication storage and delivery device has been properly shaken in response to determining that the medication storage and delivery device has been shaken, (iii) a third indication indicating that the medication storage and delivery device has been properly actuated in response to determining that the medication storage and delivery device has been actuated, (iv) a fourth indication indicating that inhalation has been properly performed in response to determining that inhalation in a first particular manner has been completed, and (v) a fifth indication indicating that breath hold has been properly performed in response to determining that the patient has held his or her breath in a second particular manner.

7. The respiratory drug delivery apparatus according to claim 6 , wherein the one or more feedback devices include a plurality of LEDs and wherein the first indication, the second indication, the third indication, the fourth indication and the fifth indication each comprise causing an associated one of the LEDs to emit light of a certain color.

8. The respiratory drug delivery apparatus according to claim 3 , wherein the feedback and compliance device includes an outer housing, wherein the outer housing including a top portion located above the opening, a bottom portion located below the opening, a front side and a rear side, the outlet extending outwardly from the front side, wherein the force sensing device is provided in the housing in the bottom portion.

9. The respiratory drug delivery apparatus according to claim 8 , wherein the bottom portion includes a channel extending completely therethrough from the rear side to the front side, the channel being structured to allow fluid flow through the housing, and wherein the flow sensor is positioned in the bottom portion adjacent to the channel.

10. The respiratory drug delivery apparatus according to claim 8 , wherein the one or more feedback devices include a plurality of LEDs provided in the top portion on the front side of the housing.

11. The respiratory drug delivery apparatus according to claim 1 , wherein the feedback and compliance device includes a housing defining the opening, the housing including a top portion located above the opening, a bottom portion located below the opening, a front side and a rear side, the outlet extending outwardly from the front side, and wherein the infra-red sensors are provided in the top portion on the front side.

12. The respiratory drug delivery apparatus according to claim 1 , wherein the one or more feedback devices include a plurality of LEDs, and wherein the processing unit is programmed to cause selected ones of the LEDs to emit light of a certain color based on an output of at least one of the one or more sensors, the feedback information comprising the light of a certain color.

13. The respiratory drug delivery apparatus according to claim 1 , wherein the one or more feedback devices include a speaker, and wherein the processing unit is programmed to cause the speaker to provide the audible instructions relating to proper use of the respiratory drug delivery apparatus based on an output of at least one of the one or more sensors.

14. The respiratory drug delivery apparatus according to claim 1 , w

Assignees

• Von Hollen Dirk Ernest
• Denyer Jonathan Stanley Harold
• Koninkl Philips Nv

Inventors

• Von Hollen Dirk Ernest
• Denyer Jonathan Stanley Harold

Classifications

• A61M2205/582

  by tactile feedback · CPC title

• A61M15/0005

  with means for agitating the medicament · CPC title

• A61M2016/0021

  with a proportional output signal, e.g. from a thermistor · CPC title

• A61M2205/502

  User interfaces, e.g. screens or keyboards · CPC title

• A61M11/006

  operated by applying mechanical pressure to the liquid to be sprayed or atomised · CPC title