Paper-based chemical assay devices with improved fluidic structures

Patent metadata

Field	Value
Publication number	US-9346048-B2
Application number	US-201414312128-A
Country	US
Kind code	B2
Filing date	Jun 23, 2014
Priority date	Jun 23, 2014
Publication date	May 24, 2016
Grant date	May 24, 2016

Abstract

A chemical assay device includes a hydrophilic substrate and one or more hydrophobic structures that extend from a first side of the hydrophilic substrate to a second side of the hydrophilic substrate. A hydrophobic structure in the hydrophilic substrate forms a fluid barrier wall that extends from the first side of the hydrophilic substrate to the second side of the hydrophilic substrate with a deviation of less than 20° from a perpendicular axis between the first side and the second side.

First claim

What is claimed is:

1. A chemical assay device comprising:
a first hydrophilic substrate, the first hydrophilic substrate having a first side and a second side, a predetermined length and width, and a thickness of not more than 1 millimeter;
a first hydrophobic structure formed in the first hydrophilic substrate from a hydrophobic material and penetrating through substantially the thickness of the first hydrophilic substrate from the first side to the second side, the hydrophobic material in the first hydrophobic structure occupying more than 50% of a predetermined void volume fraction of the hydrophilic substrate and the first hydrophobic structure forming a fluid barrier wall in the first hydrophilic substrate with a surface of the fluid barrier wall extending through the thickness of the first hydrophilic substrate with a deviation from perpendicular of less than 20° from the first side and second side of the first hydrophilic substrate;
a second hydrophilic substrate having a first side and a second side, the first side of the second hydrophilic substrate engaging the second side of the first hydrophilic substrate, and the second hydrophilic substrate having another predetermined length, width, and thickness of not more than 1 millimeter; and
a second hydrophobic structure formed in the second hydrophilic substrate and the first hydrophilic substrate to bond the first hydrophilic substrate and the second hydrophilic substrate together, the hydrophobic material in the second hydrophobic structure extending from a second arrangement of the hydrophobic material formed on only the first side of the second hydrophilic substrate and penetrating both the first hydrophilic substrate and the second hydrophilic substrate.

2. The chemical assay device of claim 1 wherein the first hydrophobic structure substantially comprises hydrophobic material formed in a first arrangement of the hydrophobic material on the first side of the hydrophilic substrate formed prior to formation of the first hydrophobic structure and a spread factor corresponding to an increase in width from a first width of the first arrangement of the hydrophobic material to a second width of the hydrophobic structure does not exceed 3.0.

3. The chemical assay device of claim 1 wherein the first hydrophobic structure substantially comprises hydrophobic material in a first arrangement of the hydrophobic material on the first side of the hydrophilic substrate formed prior to formation of the first hydrophobic structure and a spread factor corresponding to an increase in width from a first width of the first arrangement of the hydrophobic material to a second width of the hydrophobic structure does not exceed 2.0.

4. The chemical assay device of claim 2 , a thickness of the first arrangement of the hydrophobic material formed on the first side of the first hydrophilic substrate prior to penetration of the hydrophobic material to form the first hydrophobic structure does not exceed 0.4 millimeters.

5. The chemical assay device of claim 1 wherein the first hydrophilic substrate substantially comprises filter paper.

6. The chemical assay device of claim 1 wherein the hydrophobic material substantially comprises wax.

7. The chemical assay device of claim 1 wherein the hydrophobic material substantially comprises a phase-change ink.

8. The chemical assay device of claim 1 , the second hydrophobic structure penetrating through substantially the thickness of the second hydrophilic substrate from the first side to the second side, the second hydrophobic structure forming another fluid barrier wall in the second hydrophilic substrate with a surface of the other fluid barrier wall extending through the thickness of the second hydrophilic substrate with a deviation from perpendicular of less than 20° from the first side and second side of the second hydrophilic substrate.

9. The chemical assay device of claim 1 wherein the second hydrophilic substrate substantially comprises filter paper.

Assignees

• Xerox Corp

Inventors

• Zhou Jing
• Kanungo Mandakini
• Jia Nancy Y
• Hong Wei

Classifications

• B01L2400/0688

  surface tension valves, capillary stop, capillary break · CPC title

• B01L2300/161

  Control and use of surface tension forces, e.g. hydrophobic, hydrophilic · CPC title

• B01L2400/086

  using baffles or other fixed flow obstructions · CPC title

• B01L2300/12

  Specific details about materials · CPC title

• B01L3/5023 Primary

  with a sample being transported to, and subsequently stored in an absorbent for analysis · CPC title