Modulation of neuronal nkcc1 as a therapeutic strategy for spasticity and related disorders
US-2024416127-A1 · Dec 19, 2024 · US
US9345875B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9345875-B2 |
| Application number | US-10484408-A |
| Country | US |
| Kind code | B2 |
| Filing date | Apr 17, 2008 |
| Priority date | Apr 17, 2008 |
| Publication date | May 24, 2016 |
| Grant date | May 24, 2016 |
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Official abstract text for this publication.
An instrument holding system for a drive system is provided. The system can include an array holder that defines at least one bore for receipt of an instrument therethrough. The at least one instrument can be adapted for insertion into an anatomy. The array holder can be in communication with the drive system to receive a driving force. The system can include a fixation plate operable to move relative to the array holder such that the fixation plate is in contact with at least a portion of the at least one instrument to couple the at least one instrument to the array holder to enable the at least one instrument to be driven by the driving force into the anatomy.
Opening claim text (preview).
What is claimed is: 1. A system comprising: a block configured to connect to and receive a driving force from a driver, wherein the block comprises (i) mating surfaces extending in a first direction, and (ii) a first bore extending through the block in a second direction perpendicular to the first direction, and wherein the first bore is configured to guide a first cannula in or out of a patient in the second direction; and a guide member connected to the block and having a second bore, wherein the second bore is aligned in the second direction with the first bore of the block; and a plate configured to be moved in the first direction relative to the block, wherein the plate comprises a pair of members and a slot, the slot extends in the first direction and is configured to receive a first electrode of the first cannula, the pair of members extends from and is perpendicular to the plate, the pair of members engages with the mating surfaces of the block such that a gap exists between the block and the plate, wherein the gap is sized such that a first depth stop mounted on the first cannula is received in the gap and on an uppermost surface of the block, and wherein when the plate is slid on the block, the gap exists between the uppermost surface of the block and an opposing inner surface of the plate, and the pair of members is configured to be slid on the mating surfaces such that (i) the first cannula is received in the slot of the plate, (ii) the first depth stop is received in the gap, and (iii) the first cannula is driven by the plate into the patient as a result of the driving force exerted on the block. 2. The system of claim 1 , wherein the cannula defines a bore for receipt of the first electrode and a microelectrode, wherein: the first electrode is a macroelectrode; and the macroelectrode defines a bore for receipt of the microelectrode. 3. The system of claim 1 , wherein: the block and the guide member define a plurality of bores for guiding a plurality of cannulas in or out of the patient; the plurality of bores comprise the first bore and the second bore; and the plurality of cannulas comprise the first cannula. 4. The system of claim 1 , wherein the plate or the block is in contact with the first depth stop when the plate is positioned relative to the block such that the first depth stop is in the gap between the plate and the block. 5. The system of claim 1 , wherein: when the plate is positioned relative to the block such that the first depth stop is in the gap between the plate and the block, the plate is in contact with a surface of the first depth stop; and when in contact with the surface of the first depth stop, the plate and the block prevent movement of the first depth stop relative to the plate and the block. 6. The system of claim 1 , wherein: the mating surfaces of the block are surfaces of two or more structural elements of the block; and the two or more structural elements include a groove, a notch, a slot, an indentation, or a dovetail. 7. A system comprising: a first cannula; a second cannula; a support member configured to connect to and receive a driving force from a drive system; a U-shaped member connected to the support member, wherein the U-shaped member comprises a bore, wherein the bore extends in a first direction and is configured to receive the first cannula, wherein the first cannula extends through the bore and comprises a first electrode, and wherein the U-shaped member comprises a plurality of slots extending in a second direction; and a plate configured to be slid in the plurality of slots to engage with and limit movement of the first electrode of the first cannula relative to the U-shaped member in the first direction, wherein when the plate is slid in the plurality of slots, (i) a gap exists between an inner surface of the U-shaped member and an opposing inner surface of the plate, (ii) the gap is sized to receive a plurality of depth stops, and (iii) the inner surface of the U-shaped member is in contact with the plurality of depth stops, wherein the plurality of depth stops are respectively mounted on the first cannula and the second cannula, wherein the plate is configured to drive the first electrode into a patient as a result of the driving force exerted on the support member, wherein the first electrode comprises a first connector, and wherein the first connector is at a first voltage potential, and wherein the second cannula is disposed in a second bore of the U-shaped member, wherein the second cannula comprises a second electrode, wherein the second electrode comprises a second connector, and wherein the second connector is at a second voltage potential. 8. The system of claim 7 , wherein: the first electrode comprises a third bore; the third bore of the first electrode is configured to receive a third electrode; and the U-shaped member is configured to engage with the plate such that the plate drives the first electrode and the third electrode into the patient as a result of the driving force exerted on the support member. 9. The system of claim 7 , wherein: the plurality of slots comprise a first pair of slots and a second pair of slots; while the plate is in the first pair of slots, a gap between the plate and the U-shaped member is such that the plate is configured to drive the first electrode and not a third electrode of the first cannula into the patient; and while the plate is in the second pair of slots, the gap between the plate and the U-shaped member is such that the plate is configured to drive the first electrode and the third electrode into the patient. 10. The system of claim 7 , wherein: the first electrode is a macroelectrode; the first cannula comprises a microelectrode; and the macroelectrode defines a bore in which the microelectrode is received. 11. The system of claim 7 , wherein the plate is configured to contact and drive the plurality of depth stops in the first direction. 12. The system of claim 1 , wherein the the gap is sized such that a plurality of depth stops mounted on a plurality of electrodes of the first cannula fit between the plate and the block; the plurality of electrodes comprise the first electrode and a second electrode; the plurality of depth stops comprise the first depth stop and a second depth stop; the first depth stop is on the first electrode; and the second depth stop is on the second electrode. 13. The system of claim 1 , further comprising the first cannula, wherein the first cannula comprises: the first electrode; and a second electrode, wherein the second electrode is disposed in the first electrode. 14. The system of claim 1 , further comprising: the first cannula extending through the first bore, wherein the first electrode comprises a first connector, wherein the first connector is at a first voltage potential, and wherein the block comprises a third bore; and a second cannula disposed in the third bore, wherein the second cannula comprises a second electrode, wherein the second electrode comprises a second connector, and wherein the second connector is at a second voltage potential. 15. The system of claim 9 , wherein: when the plate is in the first pair of slots, the gap is sized such that the plurality of depth stops are locked between the plate and the U-shaped member; and when the plate is in the second pair of slots, the gap is sized such that another depth stop is locked between the plate and the U-shaped member. 16. The system of claim 1 , wherein: the first cannula extends through only a single bore
Coupling (A61B2017/0046 takes precedence) · CPC title
Human Necessities · mapped topic
Electrodes for brain stimulation · CPC title
including a base for support on the body · CPC title
Anchoring of brain electrode systems, e.g. within burr hole · CPC title
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