Gasket for syringe and syringe having gasket

Patent metadata

Field	Value
Publication number	US-9345837-B2
Application number	US-201514600552-A
Country	US
Kind code	B2
Filing date	Jan 20, 2015
Priority date	Dec 28, 2007
Publication date	May 24, 2016
Grant date	May 24, 2016

Abstract

A gasket for use in a syringe so formed as to liquid-tightly and slidably contact an inner surface of an outer cylinder of the syringe, the gasket including a gasket body made of an elastic body and a coating layer formed on a portion thereof which contacts at least the syringe, wherein the coating layer includes a composition containing a silicone resin which includes a condensate of a reactive silicone resin having a terminal silanol group and which has a siloxane bond derived from the silanol group, and does not contain solid fine particles.

First claim

The invention claimed is:

1. A gasket for use in a syringe so formed as to liquid-tightly and slidably contact an inner surface of an outer cylinder of said syringe,
said gasket comprising a gasket body made of an elastic body and a coating layer formed on a portion thereof which contacts at least said syringe,
wherein said coating layer comprises a composition containing a silicone resin which comprises a condensate of a reactive silicone having a terminal silanol group at both terminals thereof, and wherein the condensate contains a siloxane bond derived from said silanol group, wherein said coating layer does not contain solid fine particles,
wherein said composition contains an alkylalkoxysilane or a phenylalkoxysilane as a second silicone compound different from said silicone resin having said siloxane bond, an aminoalkylalkoxysilane or a glycidoxyalkylalkoxysilane as a third silicone compound, and
said gasket has a plunger which is mounted on said gasket body or is capable of being mounted thereon.

2. The gasket for use in the syringe according to claim 1 , wherein said silicone resin is thermosetting.

3. The gasket for use in the syringe according to claim 1 , wherein said coating layer has a thickness of 1 to 30 μm.

4. The gasket for use in the syringe according to claim 1 , wherein an initial sliding resistance value of said coating layer is not more than a maximum value of a dynamic sliding resistance value thereof.

5. A syringe comprising an outer cylinder; and the gasket according to claim 1 , which is slidably accommodated inside said outer cylinder.

6. The syringe according to claim 5 , wherein the syringe contains a liquid medicine.

7. The syringe according to claim 5 , wherein a dynamic sliding resistance value of said gasket when said gasket slides at a low speed of 100 mm/minute inside said outer cylinder is not more than 20 N.

8. The gasket for use in the syringe according to claim 1 , wherein said reactive silicone having the terminal silanol group at both terminals thereof is both-terminal polydimethylsiloxane silanol.

9. The gasket for use in the syringe according to claim 1 , wherein said alkylalkoxysilane is methyltrimethoxysilane.

10. The gasket for use in the syringe according to claim 1 , wherein said aminoalkylalkoxysilane is 3-aminopropyltriethoxysilane.

11. The gasket for use in the syringe according to claim 1 , wherein said glycidoxyalkylalkoxysilane is 3-glycidoxypropyltrimethoxysilane.

12. The gasket for use in the syringe according to claim 1 , wherein said reactive silicone having the terminal silanol group at both terminals thereof is both-terminal polydimethylsiloxane silanol, said aminoalkylalkoxysilane is 3-aminopropyltriethoxysilane and said glycidoxyalkylalkoxysilane is 3-glycidoxypropyltrimethoxysilane.

13. The gasket for use in the syringe according to claim 1 , wherein said coating layer is formed from a coating solution containing components composing the reactive silicone having the terminal silanol group at both terminals thereof, the alkylalkoxysilane and the aminoalkylalkoxysilane or the glycidoxyalkylalkoxysilane dispersed and suspended in purified water, and the coating layer is obtained by applying the coating solution to a surface of the gasket and thereafter curing the coating solution.

14. The gasket for use in the syringe according to claim 1 , wherein said composition contains said aminoalkylalkoxysilane as said third silicone compound and said glycidoxyalkylalkoxysilane as a fourth silicone compound.

Assignees

• Terumo Corp

Inventors

• Horiuchi Aiko
• Watanabe Eiji
• Suzuki Shigeru
• Shimoda Masami

Classifications

• A61M2005/3118

  via the distal end of a syringe, i.e. syringe end for mounting a needle cannula · CPC title

• A61M2005/3104

  Caps for syringes without needle · CPC title

• A61M5/31513 Primary

  Piston constructions to improve sealing or sliding · CPC title

• A61M2205/0222

  Materials for reducing friction · CPC title

• A61M2205/0238

  the material being a coating or protective layer · CPC title