Dialysis device

Patent metadata

Field	Value
Publication number	US-9345825-B2
Application number	US-201013377316-A
Country	US
Kind code	B2
Filing date	Jun 9, 2010
Priority date	Jun 10, 2009
Publication date	May 24, 2016
Grant date	May 24, 2016

Abstract

The invention relates to a dialysis device ( 1 ) having a dialysate circuit comprising a first dialyzer ( 3 ) and a second dialyzer ( 5 ) wherein the first dialyzer ( 3 ) is connectable to a blood circulation of a patient via a blood feed line ( 11 ) and a recirculation ( 13 ), an effluent for a retentate flow (Q effluent ) from the dialysate circuit to the second dialyzer ( 5 ) is provided and a permetate stream (Q out ) of the second dialyzer ( 5 ) in the dialysate circuit is passed to the first dialyzer ( 3 ), the second dialyzer ( 5 ) comprising a filter membrane having a cut-off value of at least 500 Da and the first dialyzer ( 3 ) comprising a filter membrane having a cut-off value exceeding that of the second dialyzer ( 5 ).

First claim

The invention claimed is:

1. A dialysis device ( 1 ) having a. dialysate circuit comprising a first dialyzer ( 3 ) having a dialysate space ( 9 ) separate from a blood space ( 7 ) and connected in the dialysate circuit through the dialysate space ( 9 ) with a second dialyzer ( 5 ), the first dialyzer ( 3 ) being connectable to the blood circulation of a patient via a dialysis circuit comprising a blood feed line ( 11 ) to the blood space ( 7 ) and a recirculation line ( 13 ) from the blood space ( 7 ),
wherein the second dialyzer ( 5 ) separates a retentate flow (Q effluent ) from a permetate stream (Q out ) and passes the permetate stream (Q out ) to the dialysate space ( 9 ) of the first dialyzer ( 3 ), the second dialyzer ( 5 ) containing a filter membrane having a cut-off value of at least 500 Da, and the first dialyzer ( 3 ) containing a filter membrane separating the dialysate space ( 9 ) from the blood space ( 7 ) and having a cut-off value higher than that of the second dialyzer ( 5 ).

2. The dialysis device according to claim l configured for introduction of a dialysate substitute (Q feed ) into the dialysate circuit in the flow direction downstream of the first dialyzer ( 3 ) and upstream of the second dialyzer ( 5 ).

3. The dialysis device according to claim 1 configured for introduction of a dialysate substitute (Q feed ) into the dialysate circuit in the flow direction downstream of the second dialyzer ( 5 ) and upstream of the first dialyzer ( 3 ).

4. The dialysis device according to claim 1 configured for introduction of a dialysate substitute into the recirculation line ( 13 ).

5. The dialysis device according to claim 1 wherein the second dialyzer ( 5 ) filter membrane has a cut-off value ranging from 1000 to 15000 Da.

6. The dialysis device according to claim 1 wherein the second dialyzer ( 5 ) is a mid-flux dialyzer having a cut-off value of the membrane of 15000-20000 Da.

7. The dialysis device according to claim 1 wherein the first dialyzer ( 3 ) is a high-flux diayzer having a cutoff value of 20000-50000 Da.

8. The dialysis device according to claim 1 configured for providing a filtration feed (Q in ) to the dialysate circuit, wherein the proportion of the permetate permeate stream (Q, out ) to the filtration feed (Q in ) is greater than 0.5.

9. The dialysis device according to claim 1 wherein the cut-off ratio of the second dialyzer ( 5 ) to the first dialyzer ( 3 ) is in the range of 1:1.5 to 1:40.

10. The dialysis device according to claim 9 wherein the cut-off ratio of the second dialyzer ( 5 ) to the first dialyzer ( 3 ) is in the range of 1:2 to 1:10.

11. The dialysis device according to claim 1 wherein clearance from the blood stream effected in the first dialyzer ( 3 ) of molecules of molecular masses of 15000 Da is at least 20% higher than clearance from the blood stream effected in the first dialyzer of molecules of molecular masses below 1000 Da.

12. The dialysis device according to claim 1 further having means for introducing a dialysate substitute into the dialysate circuit, wherein the dialysate circuit further comprises a heating device for the dialysate substitute.

Assignees

• Herrenbauer Michael
• Pohlmeier Robert
• Fresenius Medical Care De Gmbh

Inventors

• Herrenbauer Michael
• Pohlmeier Robert

Classifications

• A61M1/1633

  with more than one dialyser unit · CPC title

• A61M1/16 Primary

  with membranes · CPC title

• A61M1/3437

  downstream of the filter, e.g. post-dilution with filtrate · CPC title