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Formulation, apparatus and method for stabilizing radiopharmaceuticals
US9345792B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9345792-B2 |
| Application number | US-201113813687-A |
| Country | US |
| Kind code | B2 |
| Filing date | Aug 15, 2011 |
| Priority date | Aug 13, 2010 |
| Publication date | May 24, 2016 |
| Grant date | May 24, 2016 |
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- Title
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Abstract
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A formulation for stabilizing a radiopharmaceutical. The formulation includes a radiopharmaceutical (or a pharmaceutically acceptable salt thereof), a gas which has oxygen, a stabilizer, and a solvent.
First claim
Opening claim text (preview).
What is claimed is: 1. A formulation for stabilizing a radiopharmaceutical, the formulation comprising: a F-18 labelled radiopharmaceutical, or a pharmaceutically acceptable salt of a F-18 labelled radiopharmaceutical thereof; a gas comprising oxygen; wherein the oxygen is present in the gas in an amount of at least about 10 vol. % by total volume of gas; and where the gas is disposed in a headspace of a vial containing the F-18 labelled radiopharmaceutical or the pharmaceutically acceptable salt of the F-18 labelled radiopharmaceutical stabilizer, wherein the stabilizer is maleic acid; and an alcohol. 2. The formulation of claim 1 ; further comprising a solvent; wherein water is the solvent. 3. The formulation of claim 1 , further comprising: an inorganic salt. 4. The formulation of claim 1 , where the alcohol is present in an amount of about 1 volume percent to 10 volume percent based on the total volume of liquid.
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Classifications
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine · CPC title
Devices used in vivo and carrying the radioactive therapeutic or diagnostic agent, therapeutic or in vivo diagnostic kits, stents · CPC title
Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner (non-active ingredients are additionally classified in A61K47/00) · CPC title
- A61K51/121Primary
Solutions, i.e. homogeneous liquid formulation · CPC title
- A61K51/0402Primary
carboxylic acid carriers, fatty acids (amino acids A61K51/0406) · CPC title
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- What does patent US9345792B2 cover?
- A formulation for stabilizing a radiopharmaceutical. The formulation includes a radiopharmaceutical (or a pharmaceutically acceptable salt thereof), a gas which has oxygen, a stabilizer, and a solvent.
- Who is the assignee on this patent?
- Kolb Hartmuth C, Walsh Joseph C, Mocharla Vani P, and 3 more
- What technology area does this patent fall under?
- Primary CPC classification A61K51/121. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue May 24 2016 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).