Additional systems and methods for providing real-time anatomical guidance in a diagnostic or therapeutic procedure

Patent metadata

Field	Value
Publication number	US-9345389-B2
Application number	US-201113295662-A
Country	US
Kind code	B2
Filing date	Nov 14, 2011
Priority date	Nov 12, 2010
Publication date	May 24, 2016
Grant date	May 24, 2016

Abstract

A system and method for intra-operatively providing anatomical guidance in a diagnostic or therapeutic procedure is disclosed. In embodiments, the system includes multiple light sources configured to emit different frequencies, multiple electronic imaging devices to detect various frequencies of reflected, emitted, or scattered light. The system and method incorporate an optical probe is integral to an endoscopic device or a therapeutic laser system, optically coupled to a light source; a display for displaying at least one visual representation of data; and a controller programmed to generate at least one real-time integrated visual representation of an area of interest and to display the real-time visual representation on the display for guidance during the diagnostic or therapeutic procedure.

First claim

We claim:

1. A system for intra-operatively providing anatomical guidance in a diagnostic or therapeutic procedure, comprising:
(a) a lamp configured to emit a beam of visible light to an area of interest of a living subject;
(b) a laser configured to emit a beam of near-infrared light to the area of interest;
(c) an optical probe optically coupled to the laser but not optically coupled to the lamp, comprising an optical fiber configured to deliver the emitted beam of near-infrared light to illuminate the area of interest and configured to collect light that is scattered or emitted from a contrast agent introduced into target tissues in the area of interest, in response to illumination by the laser;
(d) a spectrometer optically coupled to the optical probe and configured to detect the collected light and to generate a corresponding signal that comprises collected light data, and wherein the optical probe is further configured to transmit the collected light to the spectrometer through the optical fiber;
(e) a first CCD or CMOS camera configured to detect visible light that is emitted from the area of interest in response to illumination by the lamp and to generate a corresponding signal comprising visible light data;
(f) a second CCD or CMOS camera configured to detect near-infrared light having a first predetermined wavelength that is emitted from the area of interest in response to illumination by the laser and to generate a corresponding signal comprising a first set of near-infrared light data;
(g) a third CCD or CMOS camera configured to detect near-infrared light having a second predetermined wavelength that is different from the first predetermined wavelength and that is emitted from the area of interest in response to illumination by the laser, and to generate a corresponding signal comprising a second set of near-infrared light data;
(h) a display for displaying at least one visual representation of data; and
(i) a central processing unit, a processor, or a microprocessor in communication with each of the lamp, laser, spectrometer, first CCD or CMOS camera, second CCD or CMOS camera, third CCD or CMOS camera, and display, and programmed to generate at least one real-time integrated visual representation of the area of interest from each of the collected light data, visible light data, first set of near-infrared light data, and second set of near-infrared light data and to display the at least one real-time visual representation on the display, for guidance during the diagnostic or therapeutic procedure.

2. A system according to claim 1 , further comprising a speaker, wherein the programmer is further programmed to generate at least one real-time aural representation of the area of interest from each of the collected light data, first set of near-infrared light data, and second set of near-infrared light data and to emit a sound for the at least one real-time aural representation through the speaker, for guidance during the diagnostic or therapeutic procedure.

3. A system according to claim 1 , wherein the optical probe is integral to an endoscopic device or a therapeutic laser system.

4. A system according to claim 1 , wherein the optical probe is integral to an endoscopic device selected from an endoscope, a colonoscope, a microscope, a surgical microscope, an arthroscope, a laparoscope, a thoracoscope, a mediastinan endoscope, a hysteroscope, a cyctoscope, a ureteroscope, a stereomicroscope, a colposcope, a fiber-optical system, or a rigid optical systems.

5. A system according to claim 1 , wherein the optical probe is integral to a borescope or a video endoscope endoscopic device.

6. A system according to claim 1 , wherein the contrast agent comprises at least one of a Raman probe and a fluorescence probe and the collected light data comprises at least one of Raman data and fluorescence data, respectively.

7. A system according to claim 6 , wherein the at least one integrated visual representation comprises a wide-field image of the area of interest generated from the visible light data, a laser excitation image of a selected area of the area of interest defined within the wide-field image and generated from at least one of the generated first set of near-infrared light data and the generated second set of near-infrared light data, and at least one of a Raman image generated from the Raman data and a fluorescence image generated from the fluorescence data, wherein the at least one of the Raman image and fluorescence image is defined within the wide-field image and the laser excitation image.

8. A system according to claim 7 , wherein the at least one of the Raman image and the fluorescence image is an overlay image on the laser excitation image.

9. An imaging system using integrated bright-field imaging, near-infrared imaging, and at least one of Raman imaging and fluorescence imaging for intra-operatively evaluating target tissues in an area of interest of a living subject, comprising:
(a) a lamp for delivering a beam of visible light to the area of interest and a laser for delivering a beam of near-infrared light to the area of interest;
(b) a Raman and fluorescence imaging device, comprising:
(i) an optical probe optically coupled to the laser but not optically coupled to the lamp for delivering the near infrared light to illuminate target tissues of the area of interest and for collecting at least one of scattered light and emitted light from a corresponding at least one of a Raman probe and a fluorescence probe that is introduced into the target tissues and illuminated by the laser; and
(ii) a spectrometer in communication with the optical probe for obtaining at least one of Raman data from the collected scattered light and fluorescence data from the collected emitted light, respectively; and

(c) a bright-field imaging system, comprising:
(i) a first CCD or CMOS camera for obtaining visible light data from visible light emitted from the area of interest in response to illumination by the lamp;
(ii) a second CCD or CMOS camera for obtaining a first set of near-infrared data from light having a first predetermined wavelength that is emitted from the area of interest in response to illumination by the laser;
(iii) a third CCD or CMOS camera for obtaining a second set of near infrared data from light having a second predetermined wavelength that is different from the first predetermined wavelength and that is emitted from the area of interest in response to illumination by the laser;
(iv) an optical port;
(v) a system lens comprising a UV-NIR compact lens and a first focusing lens group;
(vi) a trichroic prism or a pair of dichroic mirrors;
(vii) a first laser attenuating filter;
(viii) a bandpass filter;
(ix) a second laser attenuating filter;
(x) a second focusing lens group, a third focusing lens group, and a fourth focusing lens group;

wherein the optical port and the first CCD or CMOS camera define a first optical path therebetween having the trichroic prism or the pair of dichroic mirrors and the second focusing lens group, wherein the optical port and the second CCD or CMOS camera define a second optical path therebetween having the trichroic prism or dichroic mirror, the second laser attenuating filter, bandpass filter, and fourth focusing lens group, and wherein the optical port and the third CCD or CMOS camera define a third optical path therebetween having the trichroic prism or the pair of dichroic mirrors, first laser attenuating filter, and third focusing lens group.

10. An imaging system according to claim 9 , wherein the optical probe is integral to an endoscopic device or a therapeutic laser system.

11. An imaging system according to claim 9 , whe

Assignees

• Nie Shuming
• Mohs Aaron M
• Mancini Michael C
• Univ Emory

Inventors

• Nie Shuming
• Mohs Aaron M
• Mancini Michael C

Classifications

• G01J3/0272

  Handheld · CPC title

• A61B5/0075

  by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy (A61B5/0071 takes precedence) · CPC title

• A61B1/00193

  adapted for stereoscopic vision · CPC title

• A61B2017/00061

  spectrum · CPC title

• A61B5/06

  Devices, other than using radiation, for detecting or locating foreign bodies {; Determining position of diagnostic devices within or on the body of the patient} · CPC title