Oligomer-conjugate complexes and their use
US-2015018540-A1 · Jan 15, 2015 · US
Methods and compositions for modulating alpha-1-antitrypsin expression
US9340784B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9340784-B2 |
| Application number | US-201314386246-A |
| Country | US |
| Kind code | B2 |
| Filing date | Mar 19, 2013 |
| Priority date | Mar 19, 2012 |
| Publication date | May 17, 2016 |
| Grant date | May 17, 2016 |
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Abstract
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Disclosed herein are methods for decreasing AIAT mRNA and protein expression and treating, ameliorating, preventing, slowing progression, or stopping progression of fibrosis. Disclosed herein are methods for decreasing AIAT mRNA and protein expression and treating, ameliorating, preventing, slowing progression, or stopping progression of liver disease, such as, AIATD associated liver disease, and pulmonary disease, such as, AIATD associated pulmonary disease in an individual in need thereof. Methods for inhibiting AIAT mRNA and protein expression can also be used as a prophylactic treatment to prevent individuals at risk for developing a liver disease, such as, AIATD associated liver disease and pulmonary disease, such as, AIATD associated pulmonary disease.
First claim
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What is claimed is: 1. A compound comprising a modified oligonucleotide consisting of 17 to 30 linked nucleosides and comprising a nucleobase sequence comprising a portion of at least 17 contiguous nucleobases complementary to an equal length portion of nucleobases 1421-1498 of SEQ ID NO: 1, wherein the nucleobase sequence of the modified oligonucleotide is at least 90% complementary to SEQ ID NO: 1, wherein the modified oligonucleotide comprises one or more regions of alternating…
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Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Human Necessities · mapped topic
- C12N15/113Primary
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
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- What does patent US9340784B2 cover?
- Disclosed herein are methods for decreasing AIAT mRNA and protein expression and treating, ameliorating, preventing, slowing progression, or stopping progression of fibrosis. Disclosed herein are methods for decreasing AIAT mRNA and protein expression and treating, ameliorating, preventing, slowing progression, or stopping progression of liver disease, such as, AIATD associated liver disease, a…
- Who is the assignee on this patent?
- Ionis Pharmaceuticals Inc
- What technology area does this patent fall under?
- Primary CPC classification C12N15/113. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue May 17 2016 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 1 related publication on this page (citations in our corpus or others sharing the same primary CPC).