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Fusion protein comprising tumor necrosis factor related apoptosis inducing ligand and integrin ligand and use thereof
US9340596B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9340596-B2 |
| Application number | US-73900308-A |
| Country | US |
| Kind code | B2 |
| Filing date | Oct 8, 2008 |
| Priority date | Oct 23, 2007 |
| Publication date | May 17, 2016 |
| Grant date | May 17, 2016 |
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Abstract
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Provided is a fusion protein comprising a tumor necrosis factor related apoptosis inducing ligand (TRAIL), integrin ligands of αVβ3 and αVβ5 and a linking peptide. Also provided are the expression method and simple separation and purification process for the production of the fusion protein which is soluble and has high content of the polymer, and use of the fusion protein for the manufacturing of a medicament for the treatment of tumor. The fusion protein has good tumor tissue targeting property, significantly enhanced anti-tumor effect, which can also reduce the dose of the needed protein for the target treatment effect, improve the bioavailability, reduce the treatment cost, decrease and overcome the potential toxic and side effects of the tumor necrosis factor-related apoptosis inducing ligand.
First claim
Opening claim text (preview).
The invention claimed is: 1. A method for making a fusion protein comprised of an integrin ligand of SEQ ID NO: 1, a tumor necrosis factor related apoptosis inducing ligand (TRAIL) and a linking peptide connecting the TRAIL to the integrin ligand, the method comprising the steps of: constructing a polynucleotide encoding the fusion protein by performing a PCR reaction including a first PCR primer of SEQ ID NO: 3 and a second PCR primer of SEQ ID NO: 4; the polynucleotide comprisin…
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Human Necessities · mapped topic
Human Necessities · mapped topic
Chemistry & Metallurgy · mapped topic
- C07K14/4747Primary
Chemistry & Metallurgy · mapped topic
Cross-Sectional Technologies · mapped topic
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- What does patent US9340596B2 cover?
- Provided is a fusion protein comprising a tumor necrosis factor related apoptosis inducing ligand (TRAIL), integrin ligands of αVβ3 and αVβ5 and a linking peptide. Also provided are the expression method and simple separation and purification process for the production of the fusion protein which is soluble and has high content of the polymer, and use of the fusion protein for the manufacturing…
- Who is the assignee on this patent?
- Hua Zichun, Cao Lin, Nanjing University
- What technology area does this patent fall under?
- Primary CPC classification C07K14/4747. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue May 17 2016 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).