Glass compositions with improved chemical and mechanical durability

Patent metadata

Field	Value
Publication number	US-9340447-B2
Application number	US-201514701185-A
Country	US
Kind code	B2
Filing date	Apr 30, 2015
Priority date	Oct 25, 2011
Publication date	May 17, 2016
Grant date	May 17, 2016

Abstract

The embodiments described herein relate to chemically and mechanically durable glass compositions and pharmaceutical packaging formed from the same. According to one embodiment, a glass for pharmaceutical packaging includes from about 70 mol. % to about 80 mol. % SiO 2 ; from about 4 mol. % to about 8 mol. % alkaline earth oxide, the alkaline earth oxide comprising MgO and CaO; X mol. % Al 2 O 3 , wherein X is from about 4 to about 8; and Y mol. % alkali oxide comprising non-zero amounts of Na 2 O and K 2 O, wherein Y is about 9-15 mol. % and a ratio of Y:X is greater than 1.

First claim

What is claimed is:

1. A glass for pharmaceutical packaging having a glass composition comprising:
from about 70 mol. % to about 80 mol. % SiO 2 ;
from about 4 mol. % to about 8 mol. % alkaline earth oxide, the alkaline earth oxide comprising MgO and CaO;
X mol. % Al 2 O 3 , wherein X is from 4 to about 8; and
Y mol. % alkali oxide comprising non-zero amounts of Na 2 O and K 2 O, wherein a concentration of K 2 O is from 0.01 to less than 2, Y is about 9-15 mol. % and a ratio of Y:X is greater than 1.

2. The glass for pharmaceutical packaging of claim 1 , wherein the SiO 2 is present in an amount from about 74 mol. % to about 78 mol. %.

3. The glass for pharmaceutical packaging of claim 1 , wherein the alkaline earth oxide comprises a ratio (CaO (mol. %)/(CaO (mol. %)+MgO (mol. %))) is less than or equal to 0.5.

4. The glass for pharmaceutical packaging of claim 1 , wherein the alkaline earth oxide comprises from about 0.1 mol. % to about 1.0 mol. % CaO.

5. The glass for pharmaceutical packaging of claim 1 , wherein a ratio of Y:X is less than or equal to 2.

6. The glass for pharmaceutical packaging of claim 5 , wherein the alkali oxide comprises Na 2 O in an amount greater than 8 mol. %.

7. The glass for pharmaceutical packaging of claim 1 , wherein the glass composition is free of boron and compounds of boron.

8. The glass for pharmaceutical packaging of claim 1 , wherein the glass has a type HGB1 hydrolytic resistance according to ISO 719.

9. The glass for pharmaceutical packaging of claim 1 , wherein the glass has at least a class S3 acid resistance according to DIN 12116.

10. The glass for pharmaceutical packaging of claim 1 , wherein the glass has at least a class A2 base resistance according to ISO 695.

11. The glass of claim 1 , wherein a coefficient of thermal expansion of the glass is less than 70×10 −7 K −1 .

12. The glass for pharmaceutical packaging of claim 1 , wherein the glass is ion exchange strengthened and has a compressive stress layer with a depth of layer greater than or equal to 10 μm and a surface compressive stress greater than or equal to 250 MPa.

13. The glass for pharmaceutical packaging of claim 12 , wherein the glass has a type HGA1 hydrolytic resistance according to ISO 720 before and after ion exchange strengthening.

14. A glass for pharmaceutical packaging having a glass composition comprising:
from about 74 mol. % to about 80 mol. % SiO 2 ;
alkaline earth oxide comprising MgO and CaO and a ratio (CaO (mol. %)/(CaO (mol. %)+MgO (mol. %))) is greater than 0 and less than or equal to 0.5 and the CaO is from 0.1 to about 1.0 mol. %;
X mol. % Al 2 O 3 , wherein X is from about 4 to about 8; and
Y mol. % alkali oxide comprising non-zero amounts of Na 2 O and K 2 O, wherein Y is greater than about 8 mol. %, a ratio of Y:X is greater than or equal to 1, and a ratio of a concentration of B 2 O 3 (mol. %) to (Y mol. %-X mol. %) is less than or equal to 0.3.

15. The glass for pharmaceutical packaging of claim 14 , wherein the alkaline earth oxide comprises from about 3 mol. % to about 7 mol. % MgO.

16. The glass for pharmaceutical packaging of claim 14 , wherein a ratio of Y:X is less than or equal to 2.

17. The glass for pharmaceutical packaging of claim 14 , wherein the alkali oxide comprises Na 2 O in an amount greater than 8 mol. %.

18. The glass for pharmaceutical packaging of claim 14 , wherein the glass composition is free of boron and compounds of boron.

19. The glass for pharmaceutical packaging of claim 14 , wherein the glass is ion exchange strengthened and has a compressive stress layer with a depth of layer greater than or equal to 10 μm and a surface compressive stress greater than or equal to 250 MPa.

20. The glass for pharmaceutical packaging of claim 14 , wherein the glass has a type HGB1 hydrolytic resistance according to ISO 719.

21. The glass of claim 14 , wherein a coefficient of thermal expansion of the glass is less than 70×10 −7 K −1 .

22. A glass for pharmaceutical packaging having a glass composition comprising:
from about 70 mol. % to about 80 mol. % SiO 2 ;
from about 4 mol. % to about 8 mol. % alkaline earth oxide comprising MgO and CaO and a ratio (CaO (mol. %)/(CaO (mol. %)+MgO (mol. %))) is greater than 0 and less than or equal to 0.5,
X mol. % Al 2 O 3 ; and
Y mol. % alkali oxide comprising non-zero amounts of Na 2 O and K 2 O, wherein Y is about 9-14 mol. %, a ratio of Y:X is greater than or equal to 1 and less than or equal to 2, and a ratio of a concentration of B 2 O 3 (mol. %) to (Y mol. %-X mol. %) is less than or equal to 0.3.

23. The glass for pharmaceutical packaging of claim 22 , wherein the alkaline earth oxide comprises from about 3 mol. % to about 7 mol. % MgO and from about 0.1 mol. % to about 1.0 mol. % CaO.

24. The glass for pharmaceutical packaging of claim 22 , wherein the alkali oxide comprises Na 2 O in an amount greater than 8 mol. %.

25. The glass of claim 22 , wherein a coefficient of thermal expansion of the glass is less than 70×10 −7 K −1 .

26. A glass for pharmaceutical packaging having a glass composition comprising:
from about 70 mol. % to about 80 mol. % SiO 2 ;
alkaline earth oxide comprising MgO and CaO and a ratio (CaO (mol. %)/(CaO (mol. %)+MgO (mol. %))) is greater than 0 and less than or equal to 0.5;
X mol. % Al 2 O 3 , wherein X is from about 6 to about 8; and
Y mol. % alkali oxide comprising non-zero amounts of Na 2 O and K 2 O, wherein Y is from about 9 mol. % to about 15 mol. %.

27. The glass for pharmaceutical packaging of claim 26 , wherein the alkali oxide comprises Na 2 O in an amount greater than 8 mol. %.

28. The glass of claim 26 , wherein a coefficient of thermal expansion of the glass is less than 70×10 −7 K −1 .

Assignees

• Corning Inc

Inventors

• Danielson Paul Stephen
• Demartino Steven Edward
• Drake Melinda Ann
• Morena Robert Michael
• Pal Santona
• Schaut Robert Anthony

Classifications

• A61J1/065

  Rigid ampoules, e.g. glass ampoules · CPC title

• C03C2204/00

  Glasses, glazes or enamels with special properties · CPC title

• Y10T428/1317

  Multilayer [continuous layer] · CPC title

• C03C3/083 Primary

  containing aluminium oxide or an iron compound · CPC title

• A61J1/00

  Containers specially adapted for medical or pharmaceutical purposes (capsules or the like for oral use A61J3/07; specially adapted for surgical or diagnostic appliances or instruments A61B50/30; containers for radioactive substances G21F5/00) · CPC title