Systems and methods for neuromodulation using pre-recorded waveforms

Patent metadata

Field	Value
Publication number	US-9339650-B2
Application number	US-201213365549-A
Country	US
Kind code	B2
Filing date	Feb 3, 2012
Priority date	Apr 13, 2005
Publication date	May 17, 2016
Grant date	May 17, 2016

Abstract

A method is provided for neuromodulation to treat stroke. One step of the method includes recording an input waveform from a first site in the nervous system in a source subject. The first site is healthy or at least partially functioning. Next, an output waveform is applied to a second site in the nervous system of a target subject suffering from the stoke. The second site is diseased due to the stroke.

First claim

What is claimed is:

1. A method for neuromodulation to treat stroke, said method comprising the steps of:
recording an input waveform from a first site in the central nervous system of a source subject, wherein the first site is healthy; and
applying an output waveform to a second site in the nervous system of a target subject suffering from the stroke, wherein the second site is diseased due to the stroke.

2. The method of claim 1 , wherein the source subject and the target subject are different subjects.

3. The method of claim 2 , wherein the source subject is a non-human primate.

4. The method of claim 2 , wherein the second site in the nervous system of the target subject and the first site in the central nervous system of the source subject are components of the same neural pathway.

5. The method of claim 2 , wherein the second site in the nervous system of the target subject anatomically corresponds to a structure that is neurologically distal to the first site in the central nervous system of the source subject.

6. The method of claim 1 , wherein the source subject and the target subject are the same subject.

7. The method of claim 6 , wherein the second site in the nervous system of the target subject is a component of the same neural pathway that is contralateral to the first site in the central nervous system of the source subject.

8. The method of claim 6 , wherein the second site in the nervous system of the target subject is neurologically distal from the first site in the central nervous system of the source subject.

9. The method of claim 1 , further comprising:
positioning an electrode at the second site; and
applying the output waveform through the electrode.

10. The method of claim 1 , wherein the output waveform is identical to the input waveform or derived from the input waveform.

11. The method of claim 1 , further comprising modifying the input waveform to generate the output waveform.

12. The method of claim 1 , further comprising sensing a body activity.

13. The method of claim 12 , further comprising, in response to the body activity sensed, modifying the output waveform.

14. The method of claim 13 , wherein the body activity being sensed is limb motion.

15. The method of claim 1 , wherein the input waveform is recorded while the source subject is performing a task.

16. The method of claim 15 , wherein the task is a forelimb or hindlimb motor task.

17. The method of claim 1 , further comprising combining a plurality of different input waveforms to form a composite output waveform.

18. A method for neuromodulation to treat a neurological medical condition that is the result of trauma to the brain, said method comprising the steps of:
recording an input waveform from a first site in the central nervous system of a source subject, wherein the first site is healthy; and
applying an output waveform to a second site in the central nervous system of a target subject suffering from the neurological medical condition, wherein the second site is diseased as a result of the trauma to the brain.

19. The method of claim 18 , wherein the source subject and the target subject are different subjects.

20. The method of claim 19 , wherein the source subject is a non-human primate.

21. The method of claim 19 , wherein the second site in the nervous system of the target subject and the first site in the central nervous system of the source subject are components of the same neural pathway.

22. The method of claim 19 , wherein the second site in the nervous system of the target subject anatomically corresponds to a structure that is neurologically distal to the first site in the central nervous system of the source subject.

23. The method of claim 18 , wherein the source subject and the target subject are the same subject.

24. The method of claim 23 , wherein the second site in the nervous system of the target subject is a component of the same neural pathway that is contralateral to the first site in the central nervous system of the source subject.

25. The method of claim 23 , wherein the second site in the nervous system of the target subject is neurologically distal from the first site in the central nervous system of the source subject.

26. The method of claim 18 , further comprising:
positioning an electrode at the second site; and
applying the output waveform through the electrode.

27. The method of claim 18 , wherein the output waveform is identical to the input waveform or derived from the input waveform.

28. The method of claim 18 , further comprising modifying the input waveform to generate the output waveform.

29. The method of claim 18 , further comprising sensing a body activity.

30. The method of claim 29 , further comprising, in response to the body activity sensed, modifying the output waveform.

31. The method of claim 30 , wherein the body activity being sensed is limb motion.

32. The method of claim 18 , wherein the input waveform is recorded while the source subject is performing a task.

33. The method of claim 32 , wherein the task is a forelimb or hindlimb motor task.

34. The method of claim 18 , further comprising combining a plurality of different input waveforms to form a composite output waveform.

Assignees

• Rezai Ali
• Machado Andre
• Carlton Keith
• Cleveland Clinic Foundation

Inventors

• Rezai Ali
• Machado Andre
• Carlton Keith

Classifications

• A61N1/36103 Primary

  Neuro-rehabilitation; Repair or reorganisation of neural tissue, e.g. after stroke · CPC title

• A61N1/36067

  Movement disorders, e.g. tremor or Parkinson disease (stimulating motor muscle A61N1/36003) · CPC title

• A61N1/37229

  Shape or location of the implanted or external antenna · CPC title

• A61N1/00

  Electrotherapy; Circuits therefor (A61N2/00 takes precedence; irradiation apparatus A61N5/00) · CPC title

• A61N1/0529

  Electrodes for brain stimulation · CPC title