Recognition of CYP2E1 epitopes

Patent metadata

Field	Value
Publication number	US-9339531-B2
Application number	US-201013203402-A
Country	US
Kind code	B2
Filing date	Feb 26, 2010
Priority date	Feb 26, 2009
Publication date	May 17, 2016
Grant date	May 17, 2016

Abstract

A critical epitope of human cytochrome P4502E1 (CYP2E1) associated with the development of hepatic autoimmune disease, including methods and kits for diagnosis and prognosis using the critical epitope as a biomarker for hepatic autoimmune disease.

First claim

I claim:

1. An isolated cDNA which encodes a purified CYP2E1 epitope comprising the sequence of SEQ ID NO: 2, wherein the epitope is 21-30 amino acids in length.

2. An isolated cDNA having at least 90% sequence identity to the isolated cDNA of claim 1 .

3. The isolated cDNA of claim 2 , wherein the isolated cDNA has at least 95% sequence identity to the isolated cDNA of claim 1 .

4. The isolated cDNA of claim 2 , wherein the isolated cDNA has at least 99% sequence identity to the isolated cDNA of claim 1 .

Assignees

• Njoku Dolores Benedicta
• Univ Johns Hopkins

Inventors

• Njoku Dolores Benedicta

Classifications

• C12N9/0077

  with a reduced iron-sulfur protein as one donor (1.14.15) · CPC title

• G01N33/564

  for pre-existing immune complex or autoimmune disease {, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9} · CPC title

• G01N2800/50

  Determining the risk of developing a disease · CPC title

• A61P37/02

  Immunomodulators · CPC title

• C12N2770/24211

  Hepacivirus, e.g. hepatitis C virus, hepatitis G virus · CPC title