Heterocyclic modulators of cannabinoid receptors

Patent metadata

Field	Value
Publication number	US-9339486-B2
Application number	US-201514611499-A
Country	US
Kind code	B2
Filing date	Feb 2, 2015
Priority date	Jul 13, 2007
Publication date	May 17, 2016
Grant date	May 17, 2016

Abstract

Heterocyclic compounds which modulate cannabinoid receptors are presented. Pharmaceutical compositions containing these compounds, methods of using these compounds as modulators of cannabinoid receptors and processes for synthesizing these compounds are also described herein.

First claim

We claim the following:

1. A method of activating CB2 receptor comprising contacting the CB2 receptor with a CB2 receptor agonistic effective amount of a compound of formula structure I:

or a salt, ester or prodrug thereof, wherein:
R 1 is selected from the group consisting of NH, NHR 4 , NR 4 R 5 , any carbon atom of which may be optionally substituted;
R 2 is an aryl substituted alkyl;
R 3 is selected from the group consisting of hydrogen, halogen, alkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl, any carbon atom of which may be optionally substituted; and
R 4 and R 5 vary independently and are selected from the group consisting of aryl, alkyl, cycloalkyl, aralkyl, alkenyl, and alkynyl, any carbon atom of which may be optionally substituted.

2. The method of claim 1 , wherein the compound is selected from the group consisting of:

Assignees

• Cleveland Clinic Foundation

Inventors

• Attala Mohamed Naquib
• Diaz Philippe

Classifications

• C07D307/79 Primary

  with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring · CPC title

• A61K31/343 Primary

  condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone · CPC title

• A61K31/351

  not condensed with another ring · CPC title

• C07D307/80

  Radicals substituted by oxygen atoms · CPC title

• C07D405/10

  linked by a carbon chain containing aromatic rings · CPC title