Reference material for NMR, sample tube for NMR, capillary for NMR, and method for measuring NMR for a sample

Patent metadata

Field	Value
Publication number	US-9335388-B2
Application number	US-201013520420-A
Country	US
Kind code	B2
Filing date	Dec 28, 2010
Priority date	Jan 6, 2010
Publication date	May 10, 2016
Grant date	May 10, 2016

Abstract

Disclosed is a reference material for NMR, including a nitrogen-containing compound or oxygen-containing compound and a reagent for shifting a chemical shift for the nitrogen-containing compound or oxygen-containing compound. Disclosed is a sample tube for NMR, being obtainable by providing a reference material for NMR to a first tube closed at one end, providing a second tube closed at one end into the first tube, and fusing the other end of the first tube and the other end of the second tube and sealing a gap between the other end of the first tube and the other end of the second tube.

First claim

The invention claimed is:

1. A reference material for NMR measurement, comprising triazine and europium (III) as a reagent for shifting a chemical shift for triazine,
wherein a chemical shift of 1 H-NMR for triazine in deuterated chloroform is moved to greater than or equal to 9.5 ppm and less than or equal to 12 ppm by the europium (III).

2. The reference material for NMR measurement as claimed in claim 1 , wherein an equivalent ratio of the europium (III) to the triazine is 0.02 or greater.

3. A sample tube for NMR measurement, obtainable by providing the reference material for NMR measurement as claimed in claim 1 to a first tube closed at one end, providing a second tube closed at one end into the first tube, and fusing the other end of the first tube and the other end of the second tube to seal a gap between the other end of the first tube and the other end of the second tube.

4. A method for measuring NMR measurement for a sample by using a sample tube for NMR measurement, wherein the sample tube for NMR measurement is the sample tube for NMR measurement as claimed in claim 3 .

5. A capillary for NMR measurement, obtainable by providing the reference material for NMR measurement as claimed in claim 1 to a capillary closed at one end and fusing the other end of the capillary and to close the other end of the capillary.

6. A method for measuring NMR measurement for a sample by using a sample tube for NMR measurement, wherein the sample tube for NMR measurement includes the capillary for NMR measurement as claimed in claim 5 and the sample.

7. A method for measuring NMR measurement for a sample by using a reference material, wherein the reference material is the reference material for NMR measurement as claimed in claim 1 .

8. A reference material for NMR measurement comprising trimethylsilylethanesulfonamide and praseodymium (III) as a reagent for shifting a chemical shift for trimethylsilylethanesulfonamide,
wherein a chemical shift of 1 H-NMR for trimethylsilylethanesulfonamide in deuterated chloroform is moved to greater than or equal to −2 ppm and less than or equal to 0 ppm by the praseodymium MD.

9. The reference material for NMR measurement as claimed in claim 8 , wherein an equivalent ratio of the praseodymium (III) to the trimethylsilylethanesulfonamide is 0.1 or greater.

10. A sample tube for NMR measurement, obtainable by providing the reference material for NMR measurement as claimed in claim 8 to a first tube closed at one end, providing a second tube closed at one end into the first tube, and fusing the other end of the first tube and the other end of the second tube to seal a gap between the other end of the first tube and the other end of the second tube.

11. A method for measuring NMR measurement for a sample by using a sample tube for NMR measurement, wherein the sample tube for NMR measurement is the sample tube for NMR measurement as claimed in claim 10 .

12. A capillary for NMR measurement, obtainable by providing the reference material for NMR measurement as claimed in claim 8 to a capillary closed at one end, and fusing the other end of the capillary to close the other end of the capillary.

13. A method for measuring NMR measurement for a sample by using a sample tube for NMR measurement, wherein the sample tube for NMR measurement includes the capillary for NMR measurement as claimed in claim 12 and the sample.

14. A method for measuring NMR measurement for a sample by using a reference material, wherein the reference material is the reference material for NMR measurement as claimed in claim 8 .

15. A sample tube for NMR measurement, obtainable by
providing a reference material for NMR measurement to a first tube closed at one end,
providing a second tube closed at one end into the first tube such that the reference material is positioned between the first tube and the second tube, and
fusing the other end of the first tube and the other end of the second tube to seal a gap between the other end of the first tube and the other end of the second tube.

16. The sample tube for NMR measurement as claimed in claim 15 , wherein the reference material is selected from the group consisting of maleic acid, tetramethylsilane, 3-trimethylsilylpropionic acid, 1,4-dioxane, 1,4-bis(trimethylsilyl)benzene, benzenetricarboxylic acid, sodium dimethylsilapentaneslfonate, triazine, phenazine, phosphoric acid, trifluoroacetic acid, water, benzene, chloroform, methanol, and dimethyl sulfoxide.

17. A method for measuring NMR measurement for a sample by using a sample tube for NMR measurement, wherein the sample tube for NMR measurement is the sample tube for NMR measurement as claimed in claim 15 .

Assignees

• Shimada Haruo
• Ootake Keiko
• Shiseido Co Ltd

Inventors

• Shimada Haruo
• Ootake Keiko

Classifications

• G01N24/08

  by using nuclear magnetic resonance (G01N24/12 takes precedence) · CPC title

• G01R33/30 Primary

  Sample handling arrangements, e.g. sample cells, spinning mechanisms · CPC title

• G01R33/46

  NMR spectroscopy · CPC title