Specimen testing device and method thereof

Patent metadata

Field	Value
Publication number	US-9335339-B2
Application number	US-201013376007-A
Country	US
Kind code	B2
Filing date	Jun 4, 2010
Priority date	Jun 4, 2009
Publication date	May 10, 2016
Grant date	May 10, 2016

Abstract

The present invention relates to a specimen testing device and method thereof, and it is an object of the present invention to provide a compact and reliable specimen testing device and method thereof. The specimen testing device includes one, two or more test cartridge containers which comprise a plurality of accommodation parts which accommodate or can accommodate a specimen and one, two or more reagent solutions or testing tools used for testing the specimen, and which visibly display specimen information for identifying or managing the specimen and test information showing test content; an automatic testing unit which is attached with or supports the testing tools and which causes a reaction of the specimen and the reagent solution accommodated in the test cartridge containers to obtain a predetermined optical state; an optical measurement unit which measures the optical state obtained by the automatic testing unit; and a digital camera which captures an image of content including the specimen information and the test information and displayed on the one, two or more test cartridge containers to obtain image data.

First claim

The invention claimed is:

1. A specimen testing device comprising:
one, two or more test cartridge containers which comprise a plurality of accommodation parts which accommodate or can accommodate a specimen and one, two or more reagent solutions and testing tools used for testing the specimen, and which visibly display specimen information for identifying or managing the specimen and test information showing test content;
an automatic testing unit which is attached with or supports the testing tools and which causes a reaction of the specimen and the reagent solution accommodated in the test cartridge containers to obtain a predetermined optical state;
an optical measurement unit which measures the optical state obtained by the automatic testing unit; and
a digital camera which captures an image of content as one image at one image capturing position, including the specimen and test information displayed on the one, two or more test cartridge containers, to obtain image data;
wherein a part of pieces of the specimen and test information are visibly displayed as a code data corresponding to the part of pieces of the specimen and test information on the cartridge containers;
wherein the digital camera includes: an analyzing unit which analyzes whether or not there is code data in the obtained image data, and when the code data is specified, converting the code data into analyzed data matching the code data, to obtain analyzed data; and a data synthesizing unit which synthesizes the image data and the analyzed data to output;
wherein the analyzed data matches the part of pieces of the specimen and test information;
wherein the automatic testing unit has a dispenser, the dispenser including: a suction/discharging mechanism which can suck and discharge gas; a nozzle which communicates with the suction/discharging mechanism and is detachably attachable to each of the testing tools; and a moving mechanism which is provided with the nozzle relatively movably with respect to the test cartridge containers;
wherein the testing tools comprise a dispenser tip and a solid-phase built-in tip which is built in a state where an interior of the solid-phase built-in tip can be measured from outside of the solid-phase built-in tip, the test cartridge containers accommodate or can accommodate the dispenser tip and the solid-phase built-in tip so that the nozzle can be attached to each of the testing tools, and the optical measurement unit can optically measure the interior of the solid-phase built-in tip from outside of the solid-phase built-in tip;
wherein the test information comprises information associated with the solid-phase built-in tip;
wherein the solid-phase built-in tip is a carrier sealing tip having a large diameter tube attachable to the nozzle and a small diameter tube in which carriers of specified fixed positions are sealed in one row, the small diameter tube communicating with the large diameter tube and having a size that allows insertion in one or more of the plurality of accommodation parts;
wherein, with the carriers sealed in the small diameter tube of the carrier sealing tip, chemical substances and the specified fixed positions of the carriers are associated to be measured from outside the carrier sealing tip; and
wherein the optical measurement unit optically measures the interior of the carrier sealing tip by relative movement, along an axial direction of the carrier sealing tip, between the carrier sealing tip and a light receiving end of the optical measurement unit.

2. The specimen testing device according to claim 1 , wherein the test cartridge container includes: a visible recording medium which displays or can display the specimen information and the test information; and a medium attachment part to which the visible recording medium is attached, and further includes a writing mechanism which automatically writes a measurement result of the optical measurement unit in an empty area of the visible recording medium.

3. The specimen testing device according to claim 2 , wherein the writing mechanism comprises a thermal transfer printer mechanism which performs heating and printing to display a digital number.

4. The specimen testing device according to claim 2 , wherein the visible recording medium is detachably attached to the medium attaching part of the test cartridge containers.

5. The specimen testing device according to claim 1 , wherein the test cartridge containers include one, two or more wells which accommodate in advance one, two or more reagents used to test the specimen, and which are sealed with a pierceable film, and accommodate or can accommodate a piercing tip which is detachably attachable to the nozzle of the dispenser and can pierce the film.

6. The specimen testing device according to claim 1 , wherein
the automatic testing unit includes a magnetic member which can apply and remove a magnetic force to and from an inside of the dispenser tip from an outside of the dispenser tip, and
at least one well of the test cartridge containers accommodates a magnetic particle suspension in which magnetic particles are suspended in a liquid.

7. The specimen testing device according to claim 1 , wherein the automatic testing unit comprises a temperature controller which can control a temperature in at least one well of the test cartridge containers.

8. The specimen testing device according to claim 7 , wherein the automatic testing unit includes: a cap which is openable with respect to an opening part of the well where the temperature is controlled; and a cap-blocked-duration functioning mechanism which uses the suction/discharging mechanism or the moving mechanism to enable the cap to be pressed, shaken or moved when the cap blocks the opening part.

9. The specimen testing device according to claim 7 , wherein
the temperature controller includes:
a block which is provided with a translucent well accommodation hole in which the well is accommodated; and
a heating/cooling unit which heats or cools the block, and
the optical measurement unit can optically measure the interior of the well through the well accommodation hole of the block.

10. The specimen testing device according to claim 8 , further comprising a light measuring rod which can be moved by the suction/discharging mechanism or a moving mechanism, wherein
the cap has translucency and is provided to fit to a front end of the optical measurement rod; and the optical measurement unit can optically measure an interior of the well through the cap by means of the light measuring rod.

11. The specimen testing device according to claim 7 , wherein in the test cartridge containers, a mineral oil or silicon oil is accommodated, and in the well where the temperature is controlled, the mineral oil or the silicon oil is introduced.

12. A specimen testing method comprising:
visibly displaying specimen information for identifying or managing a specimen and test information showing test content, on one, two or more test cartridge containers which comprise a plurality of accommodation parts which accommodate the specimen and one, two or more reagent solutions; a dispenser tip; and a solid-phase built-in tip which is built in a state where an interior of the solid-phase built-in tip can be measured from outside of the solid-phase built-in tip, with the dispenser tip and the solid-phase built-in tip being testing tools used to test the specimen;
producing a predetermined optical state in the interior of the solid-phase built-in tip by causing a reaction of the specimen and the reagent solutions accommodated in the test cartridge containers, using: a dispenser that includes a suction/discharging mechanism w

Assignees

• Tajima Hideji
• Universal Bio Research Co Ltd

Inventors

• Tajima Hideji

Classifications

• G01N35/026 Primary

  having blocks or racks of reaction cells or cuvettes · CPC title

• G01N2035/0436

  with pre-packaged reagents, i.e. test-packs · CPC title

• G01N2035/0498

  Drawers used as storage or dispensing means for vessels or cuvettes · CPC title

• G01N21/272

  for following a reaction, e.g. for determining photometrically a reaction rate (photometric cinetic analysis) · CPC title

• B01L3/0275

  Interchangeable or disposable dispensing tips · CPC title