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US-2016220696-A1 · Aug 4, 2016 · US
Methods for preparing polymeric reagents and compositions of polymeric reagents
US9334364B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9334364-B2 |
| Application number | US-201414329612-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jul 11, 2014 |
| Priority date | Jul 29, 2005 |
| Publication date | May 10, 2016 |
| Grant date | May 10, 2016 |
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Abstract
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Methods for preparing active carbonate esters of water-soluble polymers are provided. Also provided are other methods related to the active carbonate esters of water-soluble polymers, as well as corresponding compositions.
First claim
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What is claimed is: 1. A synthetic method comprising: (a) combining a composition comprising an aprotic solvent and a hydroxy-terminated, water-soluble polymer having the following structure: CH 3 O—(CH 2 CH 2 O) n —CH 2 CH 2 —OH wherein (n) is an integer from 2 to about 4000, with a composition comprising disuccinimidyl carbonate, wherein the composition comprising the disuccinimidyl carbonate is added such that there is an excess of the disuccinimidyl carbonate relative to the hydroxy-terminated, water-soluble polymer, to thereby result in a composition comprising an active carbonate ester of the water-soluble polymer having the following structure: wherein (n) is an integer from 2 to about 4000, and unreacted disuccinimidyl carbonate; (b) adding a composition comprising a reactive molecule selected from the group consisting of water, hydrogen sulfide, and a lower alkyl monobasic amine to the composition comprising the active carbonate ester of a water-soluble polymer and unreacted disuccinimidyl carbonate, wherein the composition comprising the reactive compound is added such that substantially all of the unreacted disuccinimidyl carbonate is substantially consumed wherein compositions resulting from step (a) are not isolated prior to conducting step (b).
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Classifications
Polyalkylene oxides · CPC title
containing carboxyl groups, or halides, or esters thereof · CPC title
- C08G65/33396Primary
having oxygen in addition to nitrogen · CPC title
- C08G65/48Primary
Polymers modified by chemical after-treatment · CPC title
- C08G65/329Primary
with organic compounds · CPC title
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Frequently asked questions
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- What does patent US9334364B2 cover?
- Methods for preparing active carbonate esters of water-soluble polymers are provided. Also provided are other methods related to the active carbonate esters of water-soluble polymers, as well as corresponding compositions.
- Who is the assignee on this patent?
- Nektar Therapeutics
- What technology area does this patent fall under?
- Primary CPC classification C08G65/33396. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue May 10 2016 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).