Thiazolopyrimidine modulators as immunosuppressive agents
US-9221822-B2 · Dec 29, 2015 · US
Derivatives of purinic and pyrimidinic antiviral agents and use thereof as potent anticancer agents
US9334272B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9334272-B2 |
| Application number | US-201414339491-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jul 24, 2014 |
| Priority date | Mar 30, 2007 |
| Publication date | May 10, 2016 |
| Grant date | May 10, 2016 |
How to read this patent
A practical reading order for non-experts. Skip the full description unless you need deep technical detail.
- Title
What the patent document calls the invention.
- Abstract
A short plain-language summary of the technical disclosure.
- Assignees and inventors
Who owns or filed the patent and who is credited as inventor.
- Key dates
Filing, priority, publication, and grant dates set the timeline.
- First independent claim
The legal scope of protection — read this for what is actually claimed.
- CPC / IPC classifications
Technology tags used to group this patent with similar filings.
- Citations and related patents
Prior art links and similar publications in this corpus.
Abstract
Official abstract text for this publication.
Novel N-acylated, O-acylated and (bis or tris)-N,O-acylated derivatives of purinic and pyrimidinic nucleoside analogs, pharmaceutical compositions containing same, and uses thereof for treating proliferative diseases or disorders are disclosed.
First claim
Opening claim text (preview).
What is claimed is: 1. A compound having Formula I: wherein: R 1 is H; R 2 is an acyl moiety selected from the group consisting of valproyl, 4-phenylbutyryl, cinnamoyl, 2-(4-isobutylphenyl)propionyl, 1-(butyryloxymethoxy)succinyl, 1-(valproyloxymethoxy)succinyl, 1-(4-phenylbutyryloxymethoxy)succinyl, 1-(cinnamoyloxymethoxy)succinyl, 1-(phenylacetoxymethoxy)succinyl and 1-(2-(4-isobutylphenyl)propionyloxymethoxy)succinyl; and R 3 and R 4 are each independently hydrogen or an acyl moiety selected from the group consisting of valproyl, 4-phenylbutyryl, cinnamoyl, 2-(4-isobutylphenyl)propionyl, 1-(butyryloxymethoxy)succinyl, 1-(valproyloxymethoxy)succinyl, 1-(4-phenylbutyryloxymethoxy)succinyl, 1-(cinnamoyloxymethoxy)succinyl, 1-(phenylacetoxymethoxy)succinyl and 1-(2-(4-isobutylphenyl)propionyloxymethoxy)succinyl. 2. The compound of claim 1 , wherein R 2 is selected from the group consisting of 4-phenylbutyryl, cinnamoyl and valproyl, and R 3 and R 4 are each independently selected from the group consisting of H, 4-phenylbutyryl, cinnamoyl and valproyl. 3. The compound of claim 1 , wherein R 4 is H. 4. The compound of claim 3 , wherein R 2 and R 3 are each cinnamoyl. 5. The compound of claim 3 , wherein R 2 is valproyl and R 3 is H. 6. The compound of claim 3 , wherein R 2 is 4-phenylbutyryl and R 3 is H. 7. The compound of claim 3 , wherein R 2 is 2-(4-isobutylphenyl) propionyl and R 3 is H. 8. The compound of claim 3 , wherein R 2 and R 3 are each valproyl. 9. N-valproyl-9-(2-valproyloxy) ethoxymethylguanine. 10. A pharmaceutical composition comprising the compound of claim 1 and a pharmaceutically acceptable carrier.
Assignees
Inventors
Classifications
- C07D473/18Primary
one oxygen and one nitrogen atom, e.g. guanine · CPC title
Antineoplastic agents · CPC title
Patent family
Related publications grouped by family.
External sources
Frequently asked questions
Answers are generated from the same data shown on this page.
- What does patent US9334272B2 cover?
- Novel N-acylated, O-acylated and (bis or tris)-N,O-acylated derivatives of purinic and pyrimidinic nucleoside analogs, pharmaceutical compositions containing same, and uses thereof for treating proliferative diseases or disorders are disclosed.
- Who is the assignee on this patent?
- Univ Ramot, Univ Bar Ilan
- What technology area does this patent fall under?
- Primary CPC classification C07D473/18. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue May 10 2016 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).