Compositions and soft tissue replacement methods
US-9005605-B2 · Apr 14, 2015 · US
US9334262B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9334262-B2 |
| Application number | US-201414189426-A |
| Country | US |
| Kind code | B2 |
| Filing date | Feb 25, 2014 |
| Priority date | Aug 19, 2010 |
| Publication date | May 10, 2016 |
| Grant date | May 10, 2016 |
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The specification discloses compositions and methods for treating a soft tissue defect of an individual.
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What is claimed is: 1. A method of treating a site of a soft tissue condition of an individual in need thereof, the method comprising the steps of: administering a hydrogel material to the site of the soft tissue condition, wherein said site comprises transplanted adipose tissue; and administering a compound to the site of the soft tissue condition, wherein administration of the compound promotes formation of a blood supply sufficient to support transplanted tissue, thereby treating the soft tissue condition; wherein the hydrogel comprises a glycosaminoglycan polymer; and wherein the compound is a compound having the structure of formula V wherein each dashed line represents the presence or absence of a bond; R 4 is H, C 1-6 hydrocarbyl; o is 0, 1, 2, 3, or 4; and V is CH 3 , optionally substituted aryl or optionally substituted heteroaryl, a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable amine salt thereof. 2. The method of claim 1 , wherein the compound is incorporated into a drug delivery platform comprising a biodegradable polymer matrix. 3. The method of claim 1 , wherein the hydrogel material is a porous material or solid particles. 4. The method of claim 1 , wherein glycosaminoglycan polymer is a hyaluronan polymer. 5. The method of claim 1 further comprising the step of administering adipose tissue to the site of the soft tissue condition. 6. The method of claim 1 wherein the soft tissue condition is a breast tissue condition.
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