Synthetic peptide, and cosmetic composition or pharmaceutical composition and application thereof
US-2024352069-A1 · Oct 24, 2024 · US
Cyclin based inhibitors of CDK2 and CDK4
US9328139B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9328139-B2 |
| Application number | US-201314017988-A |
| Country | US |
| Kind code | B2 |
| Filing date | Sep 4, 2013 |
| Priority date | Apr 16, 2010 |
| Publication date | May 3, 2016 |
| Grant date | May 3, 2016 |
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- Title
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Abstract
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Structural and functional analysis of peptide inhibitor binding to the cyclin D1 groove has been investigated and used to design peptides that provide the basis for structure-activity relationships, have improved binding and have potential for development as chemical biology probes, as potential diagnostics and as therapeutics in the treatment of proliferative diseases including cancer and inflammation.
First claim
Opening claim text (preview).
What is claimed is: 1. A peptide inhibitor having the sequence of SAKRRL(X3)G (SEQ ID NO: 11) in which X3 has the following structure: 2. A peptide inhibitor having the formula of RL(X3)G in which X3 has the following structure: the N-terminus of the said peptide inhibitor comprises an N-terminal N-cap: 1-(3,5-dichlorophenyl)-5-methyl-1H-1,2,4-triazole-3-carboxylic acid wherein the triazole moiety of the N-cap is optionally replaced with an isostere. 3. The peptide inhibitor according to claim 2 , the isostere is a pyrazole, furoic acid, pyrrole, or thiazole.
Assignees
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Classifications
Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor) · CPC title
Physics · mapped topic
Physics · mapped topic
- C07K7/06Primary
having 5 to 11 amino acids · CPC title
Drug targeting using structural data; Docking or binding prediction · CPC title
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- What does patent US9328139B2 cover?
- Structural and functional analysis of peptide inhibitor binding to the cyclin D1 groove has been investigated and used to design peptides that provide the basis for structure-activity relationships, have improved binding and have potential for development as chemical biology probes, as potential diagnostics and as therapeutics in the treatment of proliferative diseases including cancer and infl…
- Who is the assignee on this patent?
- Mcinnes Campbell, Liu Shu, Univ South Carolina
- What technology area does this patent fall under?
- Primary CPC classification C07K7/06. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue May 03 2016 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).