Methods and systems for treating a medical condition by promoting neural remodeling within the brain

Patent metadata

Field	Value
Publication number	US-9327069-B2
Application number	US-39356506-A
Country	US
Kind code	B2
Filing date	Mar 29, 2006
Priority date	Dec 21, 2004
Publication date	May 3, 2016
Grant date	May 3, 2016

Abstract

Methods of treating a medical condition include applying at least one stimulus to a stimulation site within the brain of a patient with an implanted stimulator in accordance with one or more stimulation parameters. The at least one stimulus is configured to promote neural remodeling within the brain of the patient. Systems for treating a medical condition include an implantable stimulator configured to apply at least one stimulus to a stimulation site within the brain of a patient in accordance with one or more stimulation parameters. The at least one stimulus is configured to promote neural remodeling within the brain of the patient.

First claim

What is claimed is:

1. A method of treating a medical condition of a patient, said method comprising:
generating an electrical stimulus in accordance with one or more stimulation parameters and
applying said electrical stimulus to a stimulation site of a brain of said patient to decrease the relative excitement between neurons that are the source of said medical condition and neural tissue surrounding said neurons, thereby inducing said neurons to break synaptic contacts and revert to a juvenile phenotype.

2. The method of claim 1 , further comprising sensing at least one indicator related to said medical condition and using said at least one sensed indicator to adjust said one or more stimulation parameters.

3. The method of claim 2 , wherein said at least one indicator comprises at least one or more of an electrical activity of said brain, a chemical level of said brain, a neurotransmitter level, a hormone level, and a medication level.

4. The method of claim 1 , wherein said stimulation site comprises at least one or more of a temporal lobe, cerebral ventricle, structure within a limbic system, pituitary gland, brainstem, and cerebral cortex.

5. The method of claim 1 , wherein said medical condition comprises at least one or more of autism, a psychological disorder, a neurodegenerative disease, a chromosomal abnormality, a bad habit, and an injury to said brain.

6. The method of claim 1 , further comprising:
adjusting said one or more stimulation parameters;
generating another electrical stimulus in accordance with said adjusted one or more stimulation parameters;
applying said other electrical stimulus to said one or more neurons to facilitate redifferentiation of said one or more neurons.

7. The method of claim 1 , wherein said one or more stimulation parameters comprises a frequency greater than 100 Hz.

8. The method of claim 1 , wherein said stimulation site includes said neurons, wherein excitement of the neurons is decreased by the application of said electrical stimulus.

9. The method of claim 1 , wherein said stimulation site includes said surrounding neural tissue, wherein the strength of the connection of neurons within said neural tissue is strengthened.

Assignees

• Foster Allison M
• Carbunaru Rafael
• Jaax Kristen N
• Whitehurst Todd K
• Boston Scient Neuromodulation

Inventors

• Foster Allison M
• Carbunaru Rafael
• Jaax Kristen N
• Whitehurst Todd K

Classifications

• A61M5/14276 Primary

  specially adapted for implantation · CPC title

• A61N1/0534

  Electrodes for deep brain stimulation · CPC title

• A61N1/37205

  Microstimulators, e.g. implantable through a cannula · CPC title

• A61M2210/0693

  Brain, cerebrum · CPC title

• A61N1/0529

  Electrodes for brain stimulation · CPC title