Implants for “load bearing” bone substitutions having hierarchical organized architecture deriving from transformation of vegetal structures

Patent metadata

Field	Value
Publication number	US-9326948-B2
Application number	US-201113884123-A
Country	US
Kind code	B2
Filing date	Nov 8, 2011
Priority date	Nov 8, 2010
Publication date	May 3, 2016
Grant date	May 3, 2016

Abstract

The present invention relates to a bone substitute comprising a core based on hydroxyapatite (HA), obtained from at least one porous wood, or based on collagen fibers and hydroxyapatite, and a shell, based on hydroxyapatite (HA) or silicon carbide (SiC), obtained from at least one wood having a lower porosity than the at least one wood of the core. The porous wood has a total porosity of between 60% and 95%, preferably between 65% and 85%, and it is selected from amongst the choices of rattan, pine, abachi and balsa wood. The wood of the shell has a porosity of between 20% and 60%, preferably between 30% and 50%. The bone substitute is utilized for the substitution and regeneration of bone, preferably for bones subjected to mechanical loads, such as long bones of the leg and arm, preferably the tibia, metatarsus, femur, humerus or radius.

First claim

The invention claimed is:

1. A bone substitute comprising a core and a shell, the shell covering at least part of an exterior surface of the core, the core comprising one or more of hydroxyapatite and substituted hydroxyapatite, the core having a first porosity, the core having a pore structure and being derived from a first wood in such a way that the pore structure of the core corresponds to a pore structure of the first wood, the first wood being selected from the group consisting of rattan, pine, abachi and balsa wood, the shell comprising one or more of hydroxyapatite and substituted hydroxyapatite, the shell having a pore structure and being derived from a second wood in such a way that the pore structure of the shell corresponds to a pore structure of the second wood, the second wood having a porosity which is less than the porosity of the first wood, the second wood being selected from the group consisting of sipo, oak, rosewood and kempas, the shell being coated with a layer comprising collagen mineralized with hydroxyapatite.

2. The bone substitute according to claim 1 , wherein said first wood has a total porosity of between 60% and 95%.

3. The bone substitute according to claim 1 , wherein said second wood has a porosity of between 30% and 50%.

4. The bone substitute according to claim 1 , wherein said core comprises substituted hydroxyapatite, wherein said substituted hydroxyapatite comprises hydroxyapatite partially substituted with ions selected from the group consisting of carbonate, magnesium, silicon and strontium ions and mixtures thereof.

5. The bone substitute according to claim 1 , wherein said shell comprises substituted hydroxyapatite, wherein said substituted hydroxyapatite comprises hydroxyapatite partially substituted with ions selected from the group consisting of carbonate, magnesium, silicon and strontium ions and mixtures thereof.

6. The bone substitute according to claim 1 , wherein said layer coating the shell further comprises hydroxyapatite partially substituted with ions selected from the group consisting of carbonate, magnesium, silicon and strontium ions and mixtures thereof.

7. The bone substitute according to claim 1 , wherein said shell has a thickness of between 1 and 5 mm.

8. The bone substitute according to claim 1 , wherein said core has a solid cylinder shape, and wherein said shell is a cylinder having a hollow portion therein of a shape corresponding to the cylinder shape of the core and of such dimensions as to accommodate the core.

9. The bone substitute according to claim 1 , wherein said second wood has a porosity of between 20% and 60%.

10. The bone substitute according to claim 1 , wherein said first wood has a porosity of between 65% and 85%.

11. The bone substitute according to claim 1 , wherein said core comprises a biphasic mixture comprising ionically substituted hydroxyapatite and β-tricalcium phosphate (beta-TCP; Ca 3 (PO 4 ) 2 ).

12. The bone substitute according to claim 1 , wherein said shell comprises a biophasic mixture comprising ionically substituted hydroxyapatite and β-tricalcium phosphate (beta-TCP; Ca 3 (PO 4 ) 2 ).

13. The bone substitute according to claim 1 , wherein said layer has a thickness of between 40 and 100 μm.

14. A bone substitute comprising a core and a shell, the shell covering at least part of an exterior surface of the core, the core comprising one or more of hydroxyapatite and substituted hydroxyapatite, the shell comprising one or more of hydroxyapatite and substituted hydroxyapatite;
the core being produced (A) by a process comprising the following steps:
(a) pyrolyzing a first wood to yield a carbon material, the first wood being selected from the group consisting of rattan, pine, abachi and balsa wood; and
(b) thereafter transforming the carbon material to yield one or more of hydroxyapatite and substitute hydroxyapatite;

OR
(B) by a process comprising the following steps:
(a) treating the first wood and then infiltrating the treated first wood with a precursor to yield a first precursor material;
(b) pyrolyzing the first precursor material to yield a second precursor material; and
(c) thereafter transforming the second precursor material to yield one or more of hydroxyapatite and substituted hydroxyapatite;

the shell being produced (A) by a process comprising the following steps:
(a) pyrolyzing a second wood to yield a carbon material, the second wood being selected from the group consisting of sipo, oak, rosewood and kempas; and
(b) thereafter transforming the carbon material to yield one or more of hydroxyapatite and substitute hydroxyapatite;

OR
(B) by a process comprising the following steps:
(a) treating the second wood and then infiltrating the treated second wood with a precursor to yield a first precursor material;
(b) pyrolyzing the first precursor material to yield a second precursor material; and
(c) thereafter transforming the second precursor material to yield one or more of hydroxyapatite and substituted hydroxyapatite;

wherein the second wood has a porosity which is less than the porosity of the first wood, the core having a pore structure which corresponds to a pore structure of the first wood, the shell having a pore structure which corresponds to a pore structure of the second wood, the shell being coated with a layer comprising collagen mineralized with hydroxyapatite.

15. A method of substituting or regenerating a bone or a bone portion, comprising a step of implanting a bone substitute according to claim 1 .

16. The method according to claim 15 , wherein said bone or bone portion is a bone or bone portion which is load-bearing.

17. The method according to claim 16 , wherein said bone or bone portion is a long bone of the leg or arm.

Assignees

• Tampieri Anna
• Sprio Simone
• Ruffini Andrea
• Will Julia
• Greil Peter
• Muller Frank
• Martinez Fernandez Julian
• Torres Raya Carmen
• Varela Feria Francisco Manuel
• Ramirez Rico Joaquin
• Harmand Marie-Francoise
• Consiglio Nazionale Ricerche

Inventors

• Tampieri Anna
• Sprio Simone
• Ruffini Andrea
• Will Julia
• Greil Peter
• Muller Frank
• Martinez Fernandez Julian
• Torres Raya Carmen
• Varela Feria Francisco Manuel
• Ramirez Rico Joaquin
• Harmand Marie-Francoise

Classifications

• A61L27/12 Primary

  Phosphorus-containing materials, e.g. apatite · CPC title

• A61L27/56

  Porous materials, {e.g. foams or sponges} · CPC title

• A61L27/24

  Collagen · CPC title

• A61K38/39

  Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG] · CPC title

• A61F2/28

  Bones · CPC title