Method of measuring an artefact removed photoplethysmographic (PPG) signal and a measurement system

Patent metadata

Field	Value
Publication number	US-9326731-B2
Application number	US-201214006265-A
Country	US
Kind code	B2
Filing date	Mar 26, 2012
Priority date	Mar 25, 2011
Publication date	May 3, 2016
Grant date	May 3, 2016

Abstract

A method of measuring an artifact removed photoplethysmographic (PPG) signal and a measurement system for measuring an artifact removed photoplethysmographic (PPG) signal are provided. The method comprises obtaining a first set of PPG signals from a plurality of detectors at respective measurement sites using a first illumination; obtaining a second set of PPG signals from the plurality of detectors using a second illumination; obtaining at least two pairs of PPG signals, each pair comprising one PPG signal from the first set and one PPG signal from the second set, and for each pair, computing an artifact reference signal to obtain a candidate PPG signal; and choosing one of the candidate PPG signals as the artifact removed PPG signal.

First claim

The invention claimed is:

1. A method of producing an artefact removed photoplethysmographic (PPG) signal, the method comprising:
obtaining a first set of PPG signals from a plurality of detectors at respective measurement sites using a first illumination;
obtaining a second set of PPG signals from the plurality of detectors using a second illumination;
obtaining at least two pairs of PPG signals, each pair comprising one PPG signal from the first set and one PPG signal from the second set;
computing an artefact reference signal based on the each pair of PPG signals using a vector subspace approach by using, for the pairs of PPG signals, artefact reference signals at an angle of between

0
∼

π
2

to a PPG signal in the respective pair of PPG signals in the vector subspace and separating the used artefact reference signals into a plurality of subspaces, further wherein from each of said plurality of subspaces, an artefact reference signal selected at the centre of the respective subspace is applied to a filter with one PPG signal from the first set and one PPG signal from the second set to reduce a vector space of artefact reference signals until an optimum artefact reference signal is identified and applied to the filter with one PPG signal from the first set and one PPG signal from the second set as a result of which a candidate PPG signal is obtained from which the artefact has been removed by the filter;
choosing one of the candidate PPG signals as the artefact removed PPG signal, wherein the step of choosing one of the candidate PPG signals comprises using one or more parameters to compare the candidate PPG signals; and
estimating vital signs using the chosen candidate PPG signal.

2. The method as claimed in claim 1 , wherein the parameters comprise an averaged standard deviation of maximum peak points and minimum peak points of each candidate PPG signal.

3. The method as claimed in claim 1 , wherein the parameters comprise a cross-correlation of two separated segments of each candidate PPG signal.

4. The method as claimed in claim 1 , further comprising applying a force at the plurality of detectors such that signal amplitudes of the first set of PPG signals and/or the second set of PPG signals are maximum.

5. The method as claimed in claim 4 , comprising computing an area under curve measurement using waveforms of the PPG signals to determine whether the signal amplitudes are maximum.

6. The method as claimed in claim 5 , wherein the computing an area under curve measurement comprises sampling each waveform and filtering each sample, further wherein the area under curve measurement is a summation of absolute values of the filtered samples.

7. The method as claimed in claim 1 , further comprising providing the first and second illumination using a light emitting diode.

8. The method as claimed in claim 7 , wherein the light emitting diode is positioned such that motion artefacts are minimized in the first set of PPG signals and/or the second set of PPG signals.

9. The method as claimed in claim 1 , wherein the first illumination is red light and the second illumination is infrared light.

10. A non-transitory computer readable data storage medium having stored thereon computer code means for instructing a processor of a measurement system for measuring an artefact removed photoplethysmographic (PPG) signal to execute a method of measuring an artefact removed PPG signal as claimed in claim 1 .

11. A measurement system configured to measure an artefact removed photoplethysmographic (PPG) signal, the system comprising,
a measurement device comprising a plurality of detectors at respective measurement sites configured to obtain a first set of PPG signals using a first illumination and configured to obtain a second set of PPG signals using a second illumination;
a computation unit configured to obtain at least two pairs of PPG signals, each pair comprising one PPG signal from the first set and one PPG signal from the second set, and the computation unit being configured to, for each pair, compute an artefact reference signal based on the each pair of PPG signals using a vector subspace approach by using, for the pairs of PPG signals, artefact reference signals at an angle of between

0
∼

π
2

to a PPG signal in the respective pair of PPG signals in the vector subspace and separating the used artefact reference signals into a plurality of subspaces, further wherein from each of said plurality of subspaces, an artefact reference signal selected at the centre of the respective subspace is applied to a filter with one PPG signal from the first set and one PPG signal from the second set to reduce a vector space of artefact reference signals until an optimum artefact reference signal is identified and applied to the filter with one PPG signal from the first set and one PPG signal from the second set as a result of which a candidate PPG signal is obtained from which the artefact has been removed by the filter; and
the computation unit being configured to choose one of the candidate PPG signals as the artefact removed PPG signal, wherein the step of choosing one of the candidate PPG signals comprises using one or more parameters to compare the candidate PPG signals,
wherein the system is configured to estimate vital signs by using use the chosen candidate PPG signal.

12. The system as claimed in claim 11 , wherein the parameters comprise an averaged standard deviation of maximum peak points and minimum peak points of each candidate PPG signal.

13. The system as claimed in claim 11 , wherein the parameters comprise a cross-correlation of two separated segments of each candidate PPG signal.

14. The system as claimed in claim 11 , further comprising a force application means for applying a force at the plurality of detectors such that signal amplitudes of the first set of PPG signals and/or the second set of PPG signals are maximum.

15. The system as claimed in claim 14 , wherein the computation unit is configured to compute an area under curve measurement using waveforms of the PPG signals to determine whether the signal amplitudes are maximum.

16. The system as claimed in claim 15 , wherein for the computing an area under curve measurement, the computation unit samples each waveform and filters each sample, and further the computation unit computes the area under curve measurement as a summation of absolute values of the filtered samples.

17. The system as claimed in claim 14 , further comprising an automatic sizing component to automatically size the measurement device for application to a subject, the automatic sizing component functioning as the force application means.

18. The system as claimed in claim 11 , further comprising a light emitting diode configured to provide the first and second illumination.

19. The system as claimed in claim 18 , wherein the light emitting diode is positioned such that motion artefacts are minimized in the first set of PPG signals and/or the second set of PPG signals.

20. The system as claimed in claim 11 , wherein the first illumination is red light and the second illumination is infrared light.

Assignees

• Naing Nyan Myo
• Md Kassim Md Irwan Bin
• Samsudin Mohamad Sulhede Bin
• Thaveeprungsriporn Visit
• Nitto Denko Corp

Inventors

• Naing Nyan Myo
• Md Kassim Md Irwan Bin
• Samsudin Mohamad Sulhede Bin
• Thaveeprungsriporn Visit

Classifications

• A61B5/7207 Primary

  of noise induced by motion artifacts · CPC title

• A61B5/0261

  using optical means, e.g. infrared light · CPC title

• A61B5/14551

  for measuring blood gases · CPC title

• A61B5/0295

  using plethysmography, i.e. measuring the variations in the volume of a body part as modified by the circulation of blood therethrough, e.g. impedance plethysmography · CPC title

• A61B5/7203 Primary

  for noise prevention, reduction or removal · CPC title