Zero dead volume robust fluidic connection system

Patent metadata

Field	Value
Publication number	US-9322811-B2
Application number	US-201213674330-A
Country	US
Kind code	B2
Filing date	Nov 12, 2012
Priority date	Nov 12, 2012
Publication date	Apr 26, 2016
Grant date	Apr 26, 2016

Abstract

A fluidic connection system may comprise a port which includes a capillary tube receptacle with an end seal face and a threaded wall. The fluidic connection system may also comprise a capillary tube that includes a front end face for sealingly abutting against the end seal face of the port. On the capillary tube, a flange may be affixed at a distance from the front end face of the capillary tube. The fluidic connection system may further comprise a fitting nut that includes an axial hole to allow the capillary tube to pass therethrough and a matching threaded wall corresponding to the threaded wall of the port. The fitting nut may be slidably coupled with the capillary tube behind the flange. The distance at which the flange is affixed may be predetermined such that when the flange is pushed forward by the fitting nut, the front end face of the capillary tube abuts directly against the end seal face of the port.

First claim

What is claimed is:

1. A fluidic connection system for use in chromatography, comprising:
a port including a capillary tube receptacle with an end seal face and a threaded wall;
a capillary tube including a front end face for sealingly abutting against the end seal face of the port;
a flange affixed on the capillary tube at a distance L 1 from the front end face of the capillary tube; and
a fitting nut including an axial hole to allow the capillary tube to pass therethrough and a matching threaded wall corresponding to the threaded wall of the port, the fitting nut slidably coupled with the capillary tube behind the flange,
wherein the distance L 1 is predetermined such that when the flange is pushed forward by the fitting nut, the front end face of the capillary tube abuts directly against the end seal face of the port.

2. The fluidic connection system of claim 1 , wherein the flange is affixed on the capillary tube by welding.

3. The fluidic connection system of claim 1 , wherein the flange is circumferentially affixed on the capillary tube.

4. The fluidic connection system of claim 1 , wherein the flange includes a flat rear face.

5. The fluidic connection system of claim 1 , wherein the flange is made of a material comprising PEEK.

6. The fluidic connection system of claim 1 , wherein a distance L 1 ' is defined as being between the front end face of the capillary tube and a most front face of the flange, in which the most front face of the flange does not touch the port.

7. The fluidic connection system of claim 6 , wherein the most front face of the flange does not touch the port when the flange is pushed forward by the fitting nut, or when the front end face of the capillary tube contacts the end seal face of the port.

8. The fluidic connection system of claim 1 , wherein the capillary tube is made of a material comprising PEEK.

9. The fluidic connection system of claim 1 , wherein the capillary tube has an outer diameter of about 1/16 inch.

10. The fluidic connection system of claim 1 , wherein the front end face of the capillary tube has a perpendicularity of ≦0.0005 inches to a longitudinal axis of the capillary tube.

11. The fluidic connection system of claim 1 , wherein the front end face of the capillary tube has a surface finish of ≦16 microns.

12. The fluidic connection system of claim 1 , wherein the fitting nut includes an internal spline formed in a head of the fitting nut for facilitating a rotation of the fitting nut.

13. The fluidic connection system of claim 12 , further comprising an insertion tool for rotating the fitting nut, wherein the insertion tool includes an external spline corresponding to the internal spline formed in the fitting nut.

14. The fluidic connection system of claim 13 , wherein the insertion tool further includes a radial slot for allowing the insertion tool to be pushed onto the capillary tube from a side.

15. The fluidic connection system of claim 14 , wherein the insertion tool includes a torque limiter to insure proper seal force for the end face of the capillary tube.

16. The fluidic connection system of claim 13 , wherein the insertion tool further includes a knurling formed on an outer periphery or on a portion of the outer periphery of the insertion tool for assisting gripping of the insertion tool.

17. The fluidic connection system of claim 13 , wherein the insertion tool further includes a bore formed in a head of the insertion tool.

18. A plug for removably connecting a port with an end seal face, the plug comprising:
a capillary tube including a front end face for sealingly abutting against the end seal face of the port;
a flange affixed on the capillary tube at a distance L 1 from the front end face of the capillary tube; and
a fitting nut including an axial hole to allow the capillary tube to pass therethrough and a matching threaded wall corresponding to a threaded wall of the port, the fitting nut slidably coupled with the capillary tube behind the flange,
wherein the distance L 1 is predetermined such that when the flange is pushed forward by the fitting nut, the front end face of the capillary tube abuts directly against the end seal face of the port.

19. A chromatography system comprising:
a device including a port, wherein the port includes a capillary tube receptacle with an end seal face and a threaded wall; and
a connection line including a plug at one end for removably connecting the port in the device, wherein the plug includes:
a capillary tube including a front end face for sealingly abutting against the end seal face of the port;
a flange affixed on the capillary tube at a distance L 1 from the front end face of the capillary tube; and
a fitting nut including an axial hole to allow the capillary tube to pass therethrough and a matching threaded wall corresponding to a threaded wall of the port, the fitting nut slidably coupled with the capillary tube behind the flange;
wherein the distance L 1 is predetermined such that when the flange is pushed forward by the fitting nut, the front end face of the capillary tube abuts directly against the end seal face of the port.

20. The chromatography system of claim 19 , further comprising at least one of an eluent generator, a sample injection valve, a column, a suppressor, or a detector.

Assignees

• Mcadams Michael John
• Liu Milton
• Proper George N
• Dionex Corp

Inventors

• Mcadams Michael John
• Liu Milton
• Proper George N

Classifications

• B01L2300/0838

  Capillaries · CPC title

• G01N30/00 Primary

  Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography {or field flow fractionation} (G01N3/00, G01N5/00, G01N7/00, G01N9/00, G01N11/00, G01N13/00, G01N15/00, G01N17/00, G01N19/00, G01N21/00, G01N22/00, G01N23/00, G01N24/00, G01N25/00, G01N27/00, G01N29/00 take precedence) · CPC title

• G01N30/6004

  end pieces · CPC title

• F16L19/065

  the wedging action being effected by means of a ring · CPC title

• B01L3/563 Primary

  Joints or fittings; Separable fluid transfer means to transfer fluids between at least two containers, e.g. connectors · CPC title