Rapid test method for evaluating the delamination tendency of glass packaging means

Patent metadata

Field	Value
Publication number	US-9322766-B2
Application number	US-201214354741-A
Country	US
Kind code	B2
Filing date	Oct 24, 2012
Priority date	Oct 27, 2011
Publication date	Apr 26, 2016
Grant date	Apr 26, 2016

Abstract

A rapid test method for evaluating the delamination in glass packaging is provided. The method includes exposing the glass packaging means to an atmosphere consisting of steam in order to form a corrosion zone; and subsequently carrying out at least one other step. The other step includes: visualizing the corrosion zone using a light microscope; visualizing the corrosion zone by a staining process with a subsequent inspection process; or removing glass components in ultrapure water and quantifying the removed glass components. The rapid test method provides a conclusion about whether a glass packaging exhibits a tendency to delaminate or not in a simple and reliable manner and in a relatively short time span.

First claim

The invention claimed is:

1. A rapid test method for evaluating the delamination tendency of glass packaging, comprising the steps of:
exposing empty glass packaging to an atmosphere of steam to form a corrosion zone; and
subsequently carrying out a further step selected from the group consisting of: visualizing the corrosion zone using a light microscope; visualizing the corrosion zone by staining and subsequent inspection; and dissolving glass components in ultrapure water and quantifying the dissolved glass components.

2. The rapid test method as claimed in claim 1 , wherein the step of exposing the empty glass packaging to the atmosphere of steam is carried out in an autoclave, wherein the empty glass packaging is exposed to steam for at least 30 minutes.

3. The rapid test method as claimed in claim 2 , wherein the empty glass packaging is exposed to steam for 1 to 8 hours.

4. The rapid test method as claimed in claim 1 , wherein the step of exposing the empty glass packaging to the atmosphere of steam is carried out at a temperature in a range of from above 100 degrees Celsius to 180 degrees Celsius.

5. The rapid test method as claimed in claim 1 , wherein the further step comprises visualizing the corrosion zone using a light microscope, and wherein the light microscope comprises a stereomicroscope or a stereomicroscope having grazing illumination.

6. The rapid test method as claimed in claim 1 , wherein the further step comprises visualizing the corrosion zone by staining and subsequent inspection, and wherein the staining is performed using methylene blue, methylene blue in water, or methylene blue alcohol.

7. The rapid test method as claimed in claim 1 , wherein the further step comprises visualizing the corrosion zone by staining and subsequent inspection, wherein the staining comprises charging a solution of methylene blue is into the empty glass packaging and allowing the charged empty glass packaging to stand at room temperature.

8. The rapid test method as claimed in claim 7 , wherein the charged empty glass packaging charged to stand at room temperature for several minutes to several hours.

9. The rapid test method as claimed in claim 7 , wherein the subsequent inspection comprises visual inspection.

10. The rapid test method as claimed in claim 1 , wherein the further step comprises dissolving glass components in ultrapure water and quantifying the dissolved glass components, wherein the step of dissolving glass components in ultrapure water comprises charging the empty glass packaging with the ultrapure water and storing the charged empty glass packaging at an elevated temperature, and wherein the step of quantifying the dissolved glass components comprises determining an amount or concentration of the glass components dissolved in the ultrapure water.

11. The rapid test method as claimed in claim 10 , wherein the elevated temperature is above 50 degrees Celsius.

12. The rapid test method as claimed in claim 1 , wherein the further step comprises dissolving glass components in ultrapure water and quantifying the dissolved glass components, wherein the step of dissolving glass components in ultrapure water comprises charging the empty glass packaging with ultrapure water and autoclaving the charged empty glass packaging at a temperature between 80 degrees Celsius and 150 degrees Celsius for a period from 0.5 to 8 hours, and wherein the step of quantifying the dissolved glass components comprises subsequently determining the amount or concentration of the glass components dissolved in the ultrapure water.

13. The rapid test method as claimed in claim 12 , wherein the period is 2 hours.

14. The rapid test method as claimed in claim 12 , wherein the amount or concentration of the glass components dissolved in the ultrapure water is determined using a method selected from the group consisting of ICP-OES, ICP-MS, and FAAS.

15. The rapid test method as claimed in claim 1 , wherein the empty glass packaging is selected from the group consisting of bottles, vials, phials, ampoules, cartridges, capsules, and syringes.

16. The rapid test method as claimed in claim 1 , further comprising cleaning the empty glass packaging means before and/or after exposing the empty glass packaging to the atmosphere of steam.

17. The rapid test method as claimed in claim 16 , wherein the cleaning comprises multiple rinsing of the empty glass packaging by charging with water, emptying the water from the empty glass packaging, and blowing dry the empty glass packaging means with inert gas.

18. The rapid test method as claimed in claim 16 , wherein the water comprises mains water, demineralized water or ultrapure water.

19. The rapid test method as claimed in claim 16 , wherein a final rinsing operation comprising rinsing with demineralized water or ultrapure water.

20. The rapid test method as claimed in claim 16 , wherein the inert gas is nitrogen.

21. The rapid test method as claimed in claim 16 , wherein the water for rinsing is at room temperature.

22. The rapid test method as claimed in claim 16 , wherein the water for rinsing is preheated to a temperature above room temperature.

23. The rapid test method as claimed in claim 22 , wherein the water for rinsing is preheated to above 50 degrees Celsius.

24. The rapid test method as claimed in claim 1 , wherein the further step comprises dissolving glass components in ultrapure water and quantifying the dissolved glass components, and wherein, before the dissolving step, the empty glass packaging is not rinsed with water.

Assignees

• Schott Ag

Inventors

• Scheumann Volker
• Klause Michaela
• Rothhaar Uwe

Classifications

• G01N21/90 Primary

  in a container or its contents (G01N21/91 takes precedence) · CPC title

• G01N21/01 Primary

  Arrangements or apparatus for facilitating the optical investigation · CPC title

• G01N21/91

  using penetration of dyes, e.g. fluorescent ink · CPC title