8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions

Patent metadata

Field	Value
Publication number	US-9321791-B2
Application number	US-201514748792-A
Country	US
Kind code	B2
Filing date	Jun 24, 2015
Priority date	Aug 21, 2002
Publication date	Apr 26, 2016
Grant date	Apr 26, 2016

Abstract

The present invention relates to substituted xanthines of general formula

wherein R 1 to R 3 are as defined herein, the tautomers, the stereoisomers, the mixtures, the prodrugs thereof and the salts thereof which have valuable pharmacological properties, particularly an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).

First claim

What is claimed is:

1. 1-[([1,5]naphthyridin-2-yl)methyl]-3-methyl-7-(2-butyn-l-yl)-8-((R)-3-amino-piperidin-1-yl)-xanthine, or a pharmaceutically acceptable salt thereof.

2. The pharmaceutically acceptable salt of the compound of claim 1 .

3. The free-base form of the compound of claim 1 .

4. A pharmaceutical composition comprising the compound of claim 1 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.

Assignees

• Boehringer Ingelheim Int

Inventors

• Himmelsbach Frank
• Langkopf Elke
• Eckhardt Matthias
• Mark Michael
• Maier Roland
• Lotz Ralf
• Tadayyon Mohammad

Classifications

• A61P3/10

  for hyperglycaemia, e.g. antidiabetics · CPC title

• A61P25/02

  for peripheral neuropathies · CPC title

• A61P27/02

  Ophthalmic agents · CPC title

• A61P3/04

  Anorexiants; Antiobesity agents · CPC title

• C07D473/04 Primary

  two oxygen atoms · CPC title