C-substituted, 1H-azoles for amphoteric, solvent-less proton conductivity
US-9217062-B2 · Dec 22, 2015 · US
Tetrazole compounds and methods of making and using same
US9321740B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9321740-B2 |
| Application number | US-201213981502-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jan 26, 2012 |
| Priority date | Jan 26, 2011 |
| Publication date | Apr 26, 2016 |
| Grant date | Apr 26, 2016 |
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- Title
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- Abstract
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Abstract
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Described herein are tetrazole compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various tetrazole compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.
First claim
Opening claim text (preview).
What is claimed is: 1. The compounds N-[1-(1H-tetrazol-5-yl)-5,6,7,8-tetrahydronaphthalen-2-yl]-benzenesulfonamide, N-[3-cyclopropyl-2-(1H-tetrazol-5-yl)-phenyl]-benzenesulfonamide, N-[3-methoxy-2-(1H-tetrazol-5-yl)-phenyl]-benzenesulfonamide, N-[3-methyl-2-(1H-tetrazol-5-yl)-phenyl]-benzenesulfonamide, N-[3-bromo-2-(1H-tetrazol-5-yl)-phenyl]-benzenesulfonamide, and pharmaceutically acceptable salts thereof. 2. A pharmaceutical composition comprising a compound of claim 1 , and a pharmaceutically acceptable carrier. 3. The composition of claim 2 , wherein the composition is formulated as a unit dose. 4. The composition of claim 2 , wherein the composition is formulated for oral administration. 5. The composition of claim 2 , wherein the composition is formulated for intravenous or subcutaneous administration. 6. A method of inducing weight loss in a patient in need thereof, comprising administering to said patient a pharmaceutically effective amount of a compound of claim 1 . 7. A method of treating and/or controlling obesity, comprising administering to a patient in need thereof an effective amount of a compound of claim 1 . 8. The method of claim 7 , wherein the patient is a human. 9. The method of claim 7 , wherein the patient has a body mass index greater than or equal to about 30 kg/m 2 before the administration. 10. The method of claim 7 , wherein the compound is administered orally or subcutaneously.
Assignees
Inventors
Classifications
Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title
Anorexiants; Antiobesity agents · CPC title
- C07D257/04Primary
Five-membered rings · CPC title
having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole · CPC title
- C07D257/06Primary
with nitrogen atoms directly attached to the ring carbon atom · CPC title
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- What does patent US9321740B2 cover?
- Described herein are tetrazole compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various tetrazole compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.
- Who is the assignee on this patent?
- Dyke Hazel Joan, Pallin Thomas David, Cramp Susan Mary, and 1 more
- What technology area does this patent fall under?
- Primary CPC classification C07D257/04. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Apr 26 2016 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).