Multifunctional metal nanoparticles having a polydopamine-based surface and methods of making and using the same

Patent metadata

Field	Value
Publication number	US-9320719-B2
Application number	US-201414294636-A
Country	US
Kind code	B2
Filing date	Jun 3, 2014
Priority date	Mar 15, 2011
Publication date	Apr 26, 2016
Grant date	Apr 26, 2016

Abstract

The present invention provides nanoparticles including a metallic core having a length along each axis of from 1 to 100 nanometers and a coating disposed on at least part of the surface of the metallic core, wherein the coating comprises polydopamine, along with methods for making and using such nanoparticles. The metallic core may be gold, silver or iron oxide and the polydopamine coating may have other substances bound to it, such as silver, targeting ligands or antibodies, or other therapeutic or imaging contrast agents. The disclosed nanoparticles can be targeted to cells for treating cancer or bacterial infections, and for use in diagnostic imaging.

First claim

We claim:

1. A method for treating cancer comprising administering to a patient having cancer cells one or more nanoparticles comprising:
(a) a metallic core consisting essentially of gold and having a length along each axis of from 1 to 100 nanometers;
(b) a coating comprising polydopamine disposed on at least part of the surface of the metallic core; and
(c) one or more cetuximab anti-cancer cell surface receptor antibodies;
whereby the one or more nanoparticles target the cancer cells and the cancer is effectively treated, and wherein the cancer is selected from the group consisting of metastatic colorectal cancer, head and neck cancer, and epidermal growth factor receptor (EGFR)-expressing breast cancer.

2. The method of claim 1 , wherein the one or more nanoparticles further comprise an additional anti-cancer agent bound to the coating.

3. The method of claim 2 , wherein the anti-cancer agent is a proteasome inhibitor.

4. The method of claim 1 , further comprising the step of exposing the nanoparticles to light.

5. A method for treating cancer, the method comprising:
administering to a patient having cancer cells one or more nanoparticles comprising:
(a) a metallic core consisting essentially of gold and having a length along each axis of from 1 to 100 nanometers;
(b) a coating comprising polydopamine disposed on at least part of the surface of the metallic core; and
(c) one or more cetuximab anti-cancer cell surface receptor antibodies; and
exposing the nanoparticles to light, whereby the one or more nanoparticles target the cancer cells and the cancer is effectively treated, and wherein the cancer is selected from the group consisting of metastatic colorectal cancer, head and neck cancer, and epidermal growth factor receptor (EGFR)-expressing breast cancer.

Assignees

• Messersmith Phillip B
• Black Iv Kvar C L
• Yi Ji
• Rivera Jose G
• Univ Northwestern

Inventors

• Messersmith Phillip B
• Black Iv Kvar C L
• Yi Ji
• Rivera Jose G

Classifications

• A61N5/062

  Photodynamic therapy, i.e. excitation of an agent · CPC title

• A61K33/26

  Iron; Compounds thereof · CPC title

• A61P35/00

  Antineoplastic agents · CPC title

• G01N21/4795

  spatially resolved investigating of object in scattering medium (in vivo A61B) · CPC title

• B82Y15/00

  Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors · CPC title