Podocyte cultures and uses thereof
US-2015376575-A1 · Dec 31, 2015 · US
Methods for identifying inhibitors of solute transporters
US9316633B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9316633-B2 |
| Application number | US-51499207-A |
| Country | US |
| Kind code | B2 |
| Filing date | Nov 16, 2007 |
| Priority date | Nov 16, 2006 |
| Publication date | Apr 19, 2016 |
| Grant date | Apr 19, 2016 |
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Abstract
Official abstract text for this publication.
Provided herein are methods for identifying and characterizing agents that alter the volume of a cell. Methods are provided for rapid screening and identification of an agent that alters the capability of a small, neutrally charged solute transporter to transport the solute across a cell membrane. The methods described herein may be used to identify and characterize inhibitors of urea transporters, to identify and characterize inhibitors of aquaporins, and to identify and characterize inhibitors of other small, neutrally charged solutes such as glucose.
First claim
Opening claim text (preview).
We claim the following: 1. A method for treating a disease or disorder associated with a urea clearance insufficiency in a subject, said method comprising administering to the subject a composition comprising a pharmaceutically suitable excipient and a compound that inhibits transport of urea by the urea transporter across a cell membrane, wherein the compound is selected from N-benzyl-4-(4-chlorophenylsulfonyl)-2-(2-fluorophenyl)oxazol-5-amine; 5-(methylthio)-4-(phenylsulfonyl)-2-p-tolyl-1H-imidazole; 2-phenyl-4-tosyl-1H-imidazole-5-thiol; and S-2-phenyl-4-(phenylsulfonyl)-1H-imidazol-5-yl benzothioate. 2. The method of claim 1 , wherein the disease or disorder is selected from a cardiovascular disease, syndrome of inappropriate antidiuretic hormone secretion (SIADH), cirrhosis, azotemia, acute renal failure, chronic renal insufficiency, fluid retention, diabetes, and abnormal uresis. 3. The method of claim 1 wherein the urea transporter is Urea Transporter-B (UT-B).
Assignees
Inventors
Classifications
- G01N33/5026Primary
on cell morphology · CPC title
involving cells · CPC title
involving blood groups or blood types {or red blood cells (white blood cells G01N33/56972)} · CPC title
Intracellular protein regulatory factors and their receptors, e.g. including ion channels · CPC title
involving urea · CPC title
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- What does patent US9316633B2 cover?
- Provided herein are methods for identifying and characterizing agents that alter the volume of a cell. Methods are provided for rapid screening and identification of an agent that alters the capability of a small, neutrally charged solute transporter to transport the solute across a cell membrane. The methods described herein may be used to identify and characterize inhibitors of urea transport…
- Who is the assignee on this patent?
- Verkman Alan S, Levin Marc Harris, Univ California
- What technology area does this patent fall under?
- Primary CPC classification G01N33/5026. Mapped technology areas include Physics.
- When was this patent published?
- Publication date Tue Apr 19 2016 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).