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Compositions and methods for recombinant synthesis of high molecular weight hyaluronic acid
US9315588B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9315588-B2 |
| Application number | US-201314376239-A |
| Country | US |
| Kind code | B2 |
| Filing date | Feb 4, 2013 |
| Priority date | Feb 3, 2012 |
| Publication date | Apr 19, 2016 |
| Grant date | Apr 19, 2016 |
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Abstract
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Provided is a novel hyaluronan synthase (HAS2), isolated nucleic acids encoding it, and expression vectors which express the novel HAS2. Also provided are cell cultures which contain cells which harbor the expression vectors, methods of using the cell cultures to produce high molecular weight hyaluronic acid, and cell culture media that contains the high molecular weight hyaluronic acid.
First claim
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We claim: 1. A population of eukaryotic cells comprising a recombinant expression vector encoding a protein, wherein the protein comprises an amino acid sequence having at least 98% amino acid homology to the sequence of SEQ ID NO:1, wherein the amino acid sequence comprises a serine at amino acid positions 178 and 301 relative to the sequence of SEQ ID NO: 1. 2. The population of eukaryotic cells of claim 1 , wherein the cells are present in an in vitro cell culture. 3. The population of eukaryotic cells of claim 2 , wherein culture medium in which the cells are cultured comprises hyaluronic acid having a molecular weight of at least 6,000 kDa. 4. The population of eukaryotic cells of claim 1 , wherein the protein comprises an amino acid sequence consisting of the sequence of SEQ ID NO:1.
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Inventors
Classifications
Hexosyltransferases (2.4.1) · CPC title
Preparation of nitrogen-containing carbohydrates · CPC title
- C08B37/0072Primary
Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates · CPC title
Hyaluronan synthase (2.4.1.212) · CPC title
using catalysts, e.g. selective catalysts · CPC title
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- What does patent US9315588B2 cover?
- Provided is a novel hyaluronan synthase (HAS2), isolated nucleic acids encoding it, and expression vectors which express the novel HAS2. Also provided are cell cultures which contain cells which harbor the expression vectors, methods of using the cell cultures to produce high molecular weight hyaluronic acid, and cell culture media that contains the high molecular weight hyaluronic acid.
- Who is the assignee on this patent?
- Gorbunova Vera, Seluanov Andrei, Univ Rochester
- What technology area does this patent fall under?
- Primary CPC classification C08B37/0072. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Apr 19 2016 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).