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Method and carrier complexes for delivering molecules to cells
US9315586B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9315586-B2 |
| Application number | US-201213422722-A |
| Country | US |
| Kind code | B2 |
| Filing date | Mar 16, 2012 |
| Priority date | May 1, 2003 |
| Publication date | Apr 19, 2016 |
| Grant date | Apr 19, 2016 |
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Abstract
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The invention relates to carrier complexes and methods for delivering molecules to cells. The carrier complexes comprises a molecule and an aromatic cationic peptide in accordance with the invention. In one embodiment, the method for delivering a molecule to a cell comprises contacting the cell with a carrier complex. In another embodiment, the method for delivering a molecule to a cell comprises contacting the cell with a molecule and an aromatic cationic peptide.
First claim
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What is claimed is: 1. A method for delivering a molecule to a cell, the method comprising contacting the cell with a carrier complex, wherein the carrier complex comprises the molecule conjugated to an aromatic cationic peptide, wherein the aromatic cationic peptide is selected from the group consisting of: Tyr-D-Arg-Phe-Lys-NH 2 (DALDA), 2′,6′-Dmt-D-Arg-Phe-Lys-NH 2 (Dmt 1 -DALDA), Phe-D-Arg-Phe-Lys-NH 2 (Phe 1 -DALDA), D-Arg-2′,6′-Dmt-Lys-Phe-NH 2 , and 2′,6′-Dmp-D-Arg-Phe-Lys-NH 2 (Dmp 1 -DALDA); and wherein the molecule is a lipid. 2. A method according to claim 1 , wherein the peptide has the formula Tyr-D-Arg-Phe-Lys-NH 2 (DALDA). 3. A method according to claim 1 , wherein the peptide has the formula 2′,6′-Dmt-D-Arg-Phe-Lys-NH 2 (Dmt 1 -DALDA). 4. A method according to claim 1 , wherein the peptide has the formula Phe-D-Arg-Phe-Lys-NH 2 (Phe 1 -DALDA). 5. A method according to claim 1 , wherein the peptide has the formula D-Arg-2′,6′-Dmt-Lys-Phe-NH 2 . 6. A method according to claim 1 , wherein the peptide has the formula 2′,6′-Dmp-D-Arg-Phe-Lys-NH 2 (Dmp 1 -DALDA). 7. A method according to claim 1 , wherein the cell is a bacterial cell. 8. A method according to claim 1 , wherein the cell is a plant cell. 9. A method according to claim 1 , wherein the cell is an animal cell. 10. A method according to claim 9 , wherein the animal cell is a mammalian cell. 11. A method according to claim 9 , wherein the cell is a neuronal cell. 12. A method according to claim 9 , wherein the cell is a renal epithelial cell. 13. A method according to claim 9 , wherein the cell is an intestinal epithelial cell. 14. A method according to claim 9 , wherein the cell is a vascular endothelial cell. 15. A method according to claim 14 , wherein the endothelial cell is a blood-brain barrier endothelial cell. 16. A method according to claim 9 , wherein the cell is a glial cell. 17. A method according to claim 9 , wherein the cell is a hepatocyte. 18. A method according to claim 1 , wherein the aromatic-cationic peptide comprises a linker. 19. A method according to claim 1 , wherein the molecule comprises a linker. 20. A method according to claim 1 , wherein the molecule and aromatic cationic peptide are chemically bonded.
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- What does patent US9315586B2 cover?
- The invention relates to carrier complexes and methods for delivering molecules to cells. The carrier complexes comprises a molecule and an aromatic cationic peptide in accordance with the invention. In one embodiment, the method for delivering a molecule to a cell comprises contacting the cell with a carrier complex. In another embodiment, the method for delivering a molecule to a cell compris…
- Who is the assignee on this patent?
- Szeto Hazel, Zhao Kesheng, Robertson Hugh, and 2 more
- What technology area does this patent fall under?
- Primary CPC classification A61K31/713. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Apr 19 2016 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).