Compositions for use as a prophylactic agent to those at risk of infection of tuberculosis, or as secondary agents for treating infected tuberculosis patients
US-2024382575-A1 · Nov 21, 2024 · US
Compositions and methods
US9315556B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9315556-B2 |
| Application number | US-200913055775-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jul 24, 2009 |
| Priority date | Jul 25, 2008 |
| Publication date | Apr 19, 2016 |
| Grant date | Apr 19, 2016 |
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- Title
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Abstract
Official abstract text for this publication.
The present invention is directed to a polypeptide which comprises: (i) an Rv1753c protein sequence; (ii) a variant of an Rv1753c protein sequence; or (iii) an immunogenic fragment of an Rv1753c protein sequence. In other aspects the invention is directed to associated polynucleotides, fusion proteins and methods for the treatment or prevention of tuberculosis.
First claim
Opening claim text (preview).
What is claimed is: 1. A pharmaceutical composition comprising: an Rv1753c polypeptide which comprises an amino acid sequence that is at least 95% identical to an amino acid sequence selected from the group consisting of SEQ ID Nos: 1 and 3-7; and a pharmaceutically acceptable carrier or excipient. 2. An immunogenic composition comprising: an Rv1753c polypeptide which comprises an amino acid sequence that is at least 95% identical to an amino acid sequence selected from the group consisting of SEQ ID Nos: 1 and 3-7 and a non-specific immune response enhancer. 3. A fusion protein comprising an Rv1753c polypeptide comprising an amino acid sequence that is at least 95% identical to an amino acid sequence selected from the group consisting of SEQ ID Nos: 1 and 3-7. 4. The composition according to claim 1 , wherein the polypeptide comprises an amino acid sequence at least 95% identical to SEQ ID NO:1. 5. The immunogenic composition according to claim 2 , wherein the polypeptide comprises an amino acid sequence at least 95% identical to SEQ ID NO:1.
Assignees
Inventors
Classifications
for tuberculosis · CPC title
Immunostimulants · CPC title
Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title
Pulmonary diseases · CPC title
Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers · CPC title
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Frequently asked questions
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- What does patent US9315556B2 cover?
- The present invention is directed to a polypeptide which comprises: (i) an Rv1753c protein sequence; (ii) a variant of an Rv1753c protein sequence; or (iii) an immunogenic fragment of an Rv1753c protein sequence. In other aspects the invention is directed to associated polynucleotides, fusion proteins and methods for the treatment or prevention of tuberculosis.
- Who is the assignee on this patent?
- Brown James, Mettens Pascal, Murphy Dennis, and 1 more
- What technology area does this patent fall under?
- Primary CPC classification A61K39/04. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Apr 19 2016 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).