Neuroactive 19-alkoxy-17-substituted steroids, prodrugs thereof, and methods of treatment using same
US-2020113916-A1 · Apr 16, 2020 · US
US9315539B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9315539-B2 |
| Application number | US-67628703-A |
| Country | US |
| Kind code | B2 |
| Filing date | Oct 1, 2003 |
| Priority date | Oct 1, 2002 |
| Publication date | Apr 19, 2016 |
| Grant date | Apr 19, 2016 |
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The present invention relates to novel 11-β estradiol ester compounds and their use as locally active estrogens in the treatment of the symptomology of menopause and to treat estrogen sensitive cancers, including breast cancer.
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The invention claimed is: 1. A method of treating the symptomology of menopause in a patient while reducing the risk that the patient develops an estrogen-sensitive cancer, the method comprising administering to said patient an effective amount of a selective estrogen receptor modulator (SERM) which has the chemical structure: Where R is a sidechain group of at least 5 non-hydr…
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