Phenylpyridine derivative and drug containing same

Patent metadata

Field	Value
Publication number	US-9315493-B2
Application number	US-201214005046-A
Country	US
Kind code	B2
Filing date	Mar 13, 2012
Priority date	Mar 14, 2011
Publication date	Apr 19, 2016
Grant date	Apr 19, 2016

Abstract

The present invention provides: a compound represented by general formula (I) below, that has both angiotensin II receptor antagonism and a PPARγ activation effect and that is useful as a preventative and/or therapeutic agent for high blood pressure, cardiac disease, arteriosclerosis, type-2 diabetes, and the like; and a drug composition containing the compound. General formula (I) (in the formula: ring A represents a pyridine ring; ring B represents a tetrazole ring or an oxadiazol-5(4H)-one ring; X represents C—R 5 or a nitrogen atom; R 1 represents an alkyl group; R 2 represents an alkyl group or a cycloalkyl group; and R 3 , R 4 , and R 5 each independently represents a hydrogen atom, a halogen atom, an alkyl group, an alkoxy group or similar.

First claim

The invention claimed is:

1. A compound which is
3-{2-{5-{[1-(5-ethoxypyrimidin-2-yl)-2-isopropyl-6-oxo-4-propyl-1,6-dihydropyrimidin-5-yl]methyl}pyridin-2-yl}phenyl}-1,2,4-oxadiazol-5(4H)-one,
or a salt thereof, or a solvate thereof.

2. A method of treating a circulatory disease, the method comprising administering an effective amount of 3-{2-{5-{[1-(5-ethoxypyrimidin-2-yl)-2-isopropyl-6-oxo-4-propyl-1,6-dihydropyrimidin-5-yl]methyl}pyridin-2-yl}phenyl}-1,2,4-oxadiazol-5(4H)-one or a salt or solvate thereof to a patient who is in need of the treatment.

3. The method of treating a circulatory disease according to claim 2 , wherein the circulatory disease is hypertension, heart disease, angina pectoris, cerebral vascular disorder, cerebral circulatory disorder, ischemic peripheral circulatory disorder, kidney disease, or arteriosclerosis.

Assignees

• Miura Toru
• Sato Seiichi
• Yamada Hajime
• Tagashira Junya
• Watanabe Toshiaki
• Sekimoto Ryohei
• Ishida Rie
• Aoki Hitomi
• Ohgiya Tadaaki
• Kowa Co

Inventors

• Miura Toru
• Sato Seiichi
• Yamada Hajime
• Tagashira Junya
• Watanabe Toshiaki
• Sekimoto Ryohei
• Ishida Rie
• Aoki Hitomi
• Ohgiya Tadaaki

Classifications

• A61P9/10

  for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis · CPC title

• A61P5/48

  of the pancreatic hormones · CPC title

• A61P3/10

  for hyperglycaemia, e.g. antidiabetics · CPC title

• A61P43/00

  Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title

• A61P9/00

  Drugs for disorders of the cardiovascular system · CPC title